Document Detail

Hospital infections, animal models and alternatives.
MedLine Citation:
PMID:  19096886     Owner:  NLM     Status:  MEDLINE    
Bacteria represent a threat to human health, especially in healthcare settings, and treatment options are limited due to increasingly common antibiotic resistance. It is, therefore, imperative that we continue to investigate the mechanisms of pathogenesis and host-pathogen interactions. Despite the fact that some bacterial pathogens are capable of infecting both humans and at least one laboratory animal species, the relevance and animal welfare implications of animal infection models are of concern. Here, we consider whether plants and lower organisms are suitable candidates to investigate certain aspects of bacterial pathogenicity. Indeed, many of the virulence factors employed by micro-organisms render the capacity to infect a range of hosts. The scope for using such models, together with 3D human "organoids", to accelerate the development and screening of novel drugs and treatment combinations for bacterial infections is considered.
R Seabra; N Bhogal
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Publication Detail:
Type:  Journal Article; Review     Date:  2008-12-19
Journal Detail:
Title:  European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology     Volume:  28     ISSN:  1435-4373     ISO Abbreviation:  Eur. J. Clin. Microbiol. Infect. Dis.     Publication Date:  2009 Jun 
Date Detail:
Created Date:  2009-05-26     Completed Date:  2009-07-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8804297     Medline TA:  Eur J Clin Microbiol Infect Dis     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  561-8     Citation Subset:  IM    
FRAME, 96-98 North Sherwood Street, Nottingham, NG1 4EE, UK.
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MeSH Terms
Animal Welfare*
Bacterial Infections*
Disease Models, Animal*
Organ Culture Techniques / methods

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