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Hospital-based surveillance for Lassa fever in Edo State, Nigeria, 2005-2008.
MedLine Citation:
PMID:  22594713     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Objectives  To estimate the burden of Lassa fever in northern and central Edo, a state in south Nigeria where Lassa fever has been reported. Methods  Blood samples were obtained from 60 patients hospitalised at the Irrua Specialist Teaching Hospital (ISTH), Irrua, with a clinical suspicion of Lassa fever and from 451 febrile outpatients seen at the ISTH and hospitals in Ekpoma, Iruekpen, Uromi, Auchi and Igarra. All samples were tested retrospectively by Lassa virus-specific RT-PCR. Outpatients were additionally screened for Lassa virus-specific antibodies by indirect immunofluorescent antibody assay. Results  Lassa virus was detected in 25 of 60 (42%) patients with a clinical suspicion of Lassa fever. The disease affected persons of all age groups and with various occupations, including healthcare workers. The clinical picture was dominated by gastrointestinal symptoms. The case fatality rate was 29%. Lassa virus was detected in 2 of 451 (0.44%) febrile outpatients, and 8 (1.8%) were positive for Lassa virus-specific IgG. Conclusions  Lassa fever contributes to hospital mortality in Edo State. The low prevalence of the disease among outpatients and the low seroprevalence may indicate that the population-level incidence is not high. Surveillance for Lassa fever should focus on the hospitalised patient.
Authors:
Deborah U Ehichioya; Danny A Asogun; Jacqueline Ehimuan; Peter O Okokhere; Meike Pahlmann; Stephan Olschläger; Beate Becker-Ziaja; Stephan Günther; Sunday A Omilabu
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-5-18
Journal Detail:
Title:  Tropical medicine & international health : TM & IH     Volume:  -     ISSN:  1365-3156     ISO Abbreviation:  -     Publication Date:  2012 May 
Date Detail:
Created Date:  2012-5-18     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9610576     Medline TA:  Trop Med Int Health     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2012 Blackwell Publishing Ltd.
Affiliation:
 Department of Medical Microbiology and Parasitology, College of Medicine, University of Lagos, Lagos, Nigeria  Redeemer's University, Ogun State, Nigeria  Department of Virology, Bernhard-Nocht-Institute for Tropical Medicine, Hamburg, Germany  Institute of Lassa Fever Research and Control, Irrua Specialist Teaching Hospital, Edo State, Nigeria  Department of Medicine, Irrua Specialist Teaching Hospital, Edo State, Nigeria.
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