Document Detail

Hormones, heart disease, and health: individualized medicine versus throwing the baby out with the bathwater.
MedLine Citation:
PMID:  21648024     Owner:  NLM     Status:  In-Data-Review    
It is increasingly axiomatic that depression has widespread adverse physiological effects and, conversely, that a variety of physiological systems impact the risk for developing depression. This convergence of depression and altered physiology is particularly dramatic during midlife-a time during which reproductive failure presages dramatic increases in prevalence of both heart disease and depression. The potentially meaningful and illuminating links between estrogen deficiency, cardiovascular disease (CVD), and depression have largely been obscured, first by assertions, subsequently repudiated, that the perimenopause was not a time of increased risk of depression, and more recently by the denegration of hormone replacement therapy by initial reports of the Women's Health Initiative. Increasingly, however, research has led to unavoidable conclusions that CVD and depression share common, mediating pathogenic processes and that these same processes are dramatically altered by the presence or absence of estrogen (E2). This review summarizes data supporting these contentions with the intent of placing depression and estrogen therapy in their proper physiologic context. Depression and Anxiety 28:E1-E15, 2011. © 2011 Wiley-Liss, Inc.
David R Rubinow; Susan S Girdler
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Depression and anxiety     Volume:  28     ISSN:  1520-6394     ISO Abbreviation:  Depress Anxiety     Publication Date:  2011 Jun 
Date Detail:
Created Date:  2011-06-07     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9708816     Medline TA:  Depress Anxiety     Country:  United States    
Other Details:
Languages:  eng     Pagination:  E1-E15     Citation Subset:  IM    
Copyright Information:
© 2011 Wiley-Liss, Inc.
Department of Psychiatry, University of North Carolina, Chapel Hill, North Carolina.
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