Document Detail

Hormone therapy and risk of myocardial infarction: a national register study.
MedLine Citation:
PMID:  18826989     Owner:  NLM     Status:  MEDLINE    
AIM: To assess the risk of myocardial infarction (MI) as a result of hormone therapy (HT), with focus on the influence of age, duration of HT, various regimens and routes, progestagen type, and oestrogen dose. METHODS AND RESULTS: All healthy Danish women (n = 698,098, aged 51-69) were followed during 1995-2001. On the basis of a central prescription registry, daily updated national capture on HT was determined. National Registers identified 4947 MI incidents. Poisson regression analyses estimated rate ratios (RRs). Overall, we found no increased risk [RR 1.03 (95% CI: 0.95-1.11)] of MI with the current HT compared with women who never used HT; age-stratified RR among women aged 51-54, 55-59, 60-64, and 65-69 years were 1.24 (1.02-1.51), 0.96 (0.82-1.12), 1.11 (0.97-1.27), and 0.92 (0.80-1.06), respectively. An increasing risk with longer duration was found for younger women, which was not observed with older age groups. In all age groups, the highest risk of MI was found with continuous HT regimen. No increased risk was found with unopposed oestrogen, cyclic combined therapy, or tibolone. Significantly lower risk was found with dermal route than oral unopposed oestrogen therapy (P = 0.04). No associations were found with progestagen type or oestrogen dose. CONCLUSION: In a National cohort study, we found that HT regimen and route of application could modify the influence of HT on the risk of MI.
Ellen Løkkegaard; Anne Helms Andreasen; Rikke Kart Jacobsen; Lars Hougaard Nielsen; Carsten Agger; Øjvind Lidegaard
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-09-30
Journal Detail:
Title:  European heart journal     Volume:  29     ISSN:  1522-9645     ISO Abbreviation:  Eur. Heart J.     Publication Date:  2008 Nov 
Date Detail:
Created Date:  2008-11-03     Completed Date:  2009-03-11     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8006263     Medline TA:  Eur Heart J     Country:  England    
Other Details:
Languages:  eng     Pagination:  2660-8     Citation Subset:  IM    
Gynaecological Clinic, Rigshospitalet, Copenhagen Ø, Denmark.
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MeSH Terms
Denmark / epidemiology
Epidemiologic Methods
Estrogen Replacement Therapy / adverse effects*
Middle Aged
Myocardial Infarction / chemically induced*,  epidemiology
Comment In:
Womens Health (Lond Engl). 2009 Jan;5(1):29-31   [PMID:  19102637 ]

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