| HORMONE THERAPY AND MAXIMAL ECCENTRIC EXERCISE ALTERS MYOSTATIN-RELATED GENE EXPRESSION IN POSTMENOPAUSAL WOMEN. | |
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MedLine Citation:
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PMID: 22395277 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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We sought to evaluate baseline mRNA values and changes in gene expression of myostatin-related factors in postmenopausal women taking hormone therapy (HT) and not taking HT following eccentric exercise. Fourteen postmenopausal women participated including 6 controls not using HT (59 ± 4 yrs, 63 ± 17 kg) and 8 women using HT (59 ± 4 yrs, 89 ± 24 kg). Participants performed 10 sets of 10 maximal eccentric repetitions of single-leg extension on a dynamometer. Muscle biopsies from the vastus lateralis were obtained from the exercised leg at baseline and 4 hours after the exercise bout. Gene expression was determined using RT-PCR for myostatin, ActRIIb (activin receptor IIb), follistatin, FLRG (follistatin-related gene), FSTL3 (follistatin-like-3) and GASP-1 (GDF-serum associated protein-1). In response to the exercise bout, myostatin and ActRIIb significantly decreased (P < 0.05) and follistatin, FLRG, FSTL3 and GASP-1 significantly increased in both groups (P < 0.05). Significantly greater changes in gene expression of all genes occurred in the HT group than in the control group after the acute eccentric exercise bout (P < 0.05). These data suggest that postmenopausal women using HT express greater myostatin-related gene expression, which may reflect a mechanism by which estrogen influences the preservation of muscle mass. Further, postmenopausal women using HT experienced a profoundly greater myostatin-related response to maximal eccentric exercise. |
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Authors:
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Christina M Dieli-Conwright; Tanya M Spektor; Judd C Rice; Fred R Sattler; E Todd Schroeder |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-3-03 |
Journal Detail:
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Title: Journal of strength and conditioning research / National Strength & Conditioning Association Volume: - ISSN: 1533-4287 ISO Abbreviation: - Publication Date: 2012 Mar |
Date Detail:
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Created Date: 2012-3-7 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9415084 Medline TA: J Strength Cond Res Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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1 Division of Biokinesiology and Physical Therapy, Clinical Exercise Research Center, 2Department of Biochemistry and Molecular Biology, USC/Norris Comprehensive Cancer Center, 3Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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