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HORMONE THERAPY AND MAXIMAL ECCENTRIC EXERCISE ALTERS MYOSTATIN-RELATED GENE EXPRESSION IN POSTMENOPAUSAL WOMEN.
MedLine Citation:
PMID:  22395277     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
We sought to evaluate baseline mRNA values and changes in gene expression of myostatin-related factors in postmenopausal women taking hormone therapy (HT) and not taking HT following eccentric exercise. Fourteen postmenopausal women participated including 6 controls not using HT (59 ± 4 yrs, 63 ± 17 kg) and 8 women using HT (59 ± 4 yrs, 89 ± 24 kg). Participants performed 10 sets of 10 maximal eccentric repetitions of single-leg extension on a dynamometer. Muscle biopsies from the vastus lateralis were obtained from the exercised leg at baseline and 4 hours after the exercise bout. Gene expression was determined using RT-PCR for myostatin, ActRIIb (activin receptor IIb), follistatin, FLRG (follistatin-related gene), FSTL3 (follistatin-like-3) and GASP-1 (GDF-serum associated protein-1). In response to the exercise bout, myostatin and ActRIIb significantly decreased (P < 0.05) and follistatin, FLRG, FSTL3 and GASP-1 significantly increased in both groups (P < 0.05). Significantly greater changes in gene expression of all genes occurred in the HT group than in the control group after the acute eccentric exercise bout (P < 0.05). These data suggest that postmenopausal women using HT express greater myostatin-related gene expression, which may reflect a mechanism by which estrogen influences the preservation of muscle mass. Further, postmenopausal women using HT experienced a profoundly greater myostatin-related response to maximal eccentric exercise.
Authors:
Christina M Dieli-Conwright; Tanya M Spektor; Judd C Rice; Fred R Sattler; E Todd Schroeder
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-3-03
Journal Detail:
Title:  Journal of strength and conditioning research / National Strength & Conditioning Association     Volume:  -     ISSN:  1533-4287     ISO Abbreviation:  -     Publication Date:  2012 Mar 
Date Detail:
Created Date:  2012-3-7     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9415084     Medline TA:  J Strength Cond Res     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
1 Division of Biokinesiology and Physical Therapy, Clinical Exercise Research Center, 2Department of Biochemistry and Molecular Biology, USC/Norris Comprehensive Cancer Center, 3Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
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