| Hormone therapy in Brazilian postmenopausal women with chronic hepatitis C: a pilot study. | |
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MedLine Citation:
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PMID: 19657792 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To evaluate liver function and hemostatic parameters in postmenopausal women who have chronic infection with the hepatitis C virus and climacteric symptoms and are undergoing hormone therapy (HT) (standard dose of transdermal continuous combined hormone therapy). DESIGN: Fifty out of 336 postmenopausal patients with chronic infection with the hepatitis C virus were selected. The non-inclusion criteria were other chronic or systemic liver diseases, severe vascular diseases, autoimmune diseases or malignant tumors. The patients were randomized into two groups: the HT group with 25 patients to be given transdermal hormone therapy (50 microg estradiol plus 170 microg norethisterone/day) and the control group with the other 25 patients (no medication). Hepatic tests (alanine aminotransferase, aspartate aminotransferase, gamma glutamyltransferase, total alkaline phosphatase, albumin, serum bilirubin) and hemostatic parameters (prothrombin time, factor V, fibrinogen) were evaluated at baseline and at 1, 4, 7 and 9 months of treatment. RESULTS: No significant changes in parameters were found in the comparison between the treated group and the controls, except for a decrease in total alkaline phosphatase (p = 0.002), presumably due to changes in bone remodelling. CONCLUSIONS: There were no changes in liver function after a 9-month treatment with transdermal estradiol plus norethisterone in symptomatic postmenopausal patients with hepatitis C. |
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Authors:
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M A F Padua; A M Fonseca; M M Deguti; V R Bagnoli; A Q Farias; G A R Maciel; J M Soares; F J Carilho; E C Baracat |
Publication Detail:
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Type: Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Climacteric : the journal of the International Menopause Society Volume: 13 ISSN: 1473-0804 ISO Abbreviation: Climacteric Publication Date: 2010 Apr |
Date Detail:
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Created Date: 2010-02-19 Completed Date: 2010-04-30 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9810959 Medline TA: Climacteric Country: England |
Other Details:
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Languages: eng Pagination: 179-86 Citation Subset: IM |
Affiliation:
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Department of Obstetrics and Gynecology, Faculdade de Medicina da Universidade de S?o Paulo, S?o Paulo, Brazil. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Cutaneous Alanine Transaminase / metabolism Alkaline Phosphatase / metabolism Aspartate Aminotransferases / metabolism Brazil Climacteric / drug effects Estrogen Replacement Therapy* Female Hepatitis C, Chronic / enzymology, physiopathology* Humans Liver / drug effects*, enzymology, physiology* Middle Aged Pilot Projects Postmenopause / metabolism Serum Albumin / metabolism gamma-Glutamyltransferase / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Serum Albumin; EC 2.3.2.2/gamma-Glutamyltransferase; EC 2.6.1.1/Aspartate Aminotransferases; EC 2.6.1.2/Alanine Transaminase; EC 3.1.3.1/Alkaline Phosphatase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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