Document Detail


Hormone therapy administration in postmenopausal women and risk of stroke.
MedLine Citation:
PMID:  21612355     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
HRT, consisting of estrogens alone, or in combination with a progestogen, is widely used for the relief of symptoms in postmenopausal women. Early observational studies have suggested that HRT might be associated with a reduced risk of cardio- and cerebro-vascular events. These encouraging results prompted randomized controlled trials assessing the risks and benefits of HRT in primary and secondary prevention of arterial vascular events. However, these clinical trials and further observational studies did not confirm the protective effect of HRT; it is now established that HRT increases the risk of stroke. This increased risk is mainly related to an increased risk of ischemic stroke. Oral estrogen alone and combined with progestogen are associated with a similar increased risk, which may be dose dependent. Conversely, a low dose of transdermal estrogens with or without a progestogen does not seem to be associated with such an increased risk of stroke, whereas the impact of tibolone, a synthetic steroid, remains uncertain. In summary, there is now a large amount of evidence demonstrating that HRT is associated with increased risk of stroke, in particular, ischemic subtype.
Authors:
Christel Renoux; Samy Suissa
Related Documents :
6637785 - The oslo study: chd risk factors, socioeconomic influences, and intervention.
1669485 - Validation of reported myocardial infarction mortality in blacks and whites. a report f...
14671465 - Influence on lifestyle measures and five-year coronary risk by a comprehensive lifestyl...
17383305 - Associations of polymorphism of p22(phox) c242t, plasma levels of vitamin e, and smokin...
9088365 - Farm-related injury mortality in new mexico, 1980-91.
21957155 - Increased risk of acute pancreatitis among tetracycline users in a swedish population-b...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Women's health (London, England)     Volume:  7     ISSN:  1745-5065     ISO Abbreviation:  Womens Health (Lond Engl)     Publication Date:  2011 May 
Date Detail:
Created Date:  2011-05-26     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101271249     Medline TA:  Womens Health (Lond Engl)     Country:  England    
Other Details:
Languages:  eng     Pagination:  355-61     Citation Subset:  IM    
Affiliation:
Center For Clinical Epidemiology, Jewish General Hospital - Lady Davis Research Institute, Montreal, Quebec, Canada.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Gender differences in the primary prevention of stroke with aspirin.
Next Document:  Pregnancy and stroke risk in women.