| Hormone replacement therapy does not affect 24-h ambulatory blood pressure in healthy non-smoking postmenopausal women. | |
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MedLine Citation:
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PMID: 12819556 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: Controversies surrounding the physiological effects of hormone replacement therapy (HRT) currently lie at the forefront of medicine. Important interindividual factors that affect blood pressure, such as smoking, body mass and sodium intake, may account for the conflicting findings seen in studies examining the effects of HRT on blood pressure. DESIGN: The study was a randomized, double-blind, placebo-controlled trial. METHODS: The effect of combination HRT and estrogen-only replacement therapy (ERT) on ambulatory blood pressure was examined in a sample of 46 healthy, normotensive, non-smoking, non-obese postmenopausal women between 45 and 65 years of age. Twenty-four hour urinary sodium excretion was examined prior to and following treatment. The women were randomized to 3 months' treatment with HRT, ERT or placebo. RESULTS: After treatment, there were no significant effects of either HRT or ERT on daytime or night-time systolic or diastolic blood pressure. Sodium excretion was similar across the groups. There were no effects of treatment on night-time blood pressure dipping. CONCLUSIONS: The findings from this prospective treatment study support the conclusion that HRT has no significant effect on daytime or night-time blood pressure in a sample of healthy, non-smoking postmenopausal women. |
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Authors:
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Paul J Mills; Noha H Farag; Scott Matthews; Richard A Nelesen; Charles C Berry; Joel E Dimsdale |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Blood pressure monitoring Volume: 8 ISSN: 1359-5237 ISO Abbreviation: Blood Press Monit Publication Date: 2003 Apr |
Date Detail:
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Created Date: 2003-06-23 Completed Date: 2004-02-20 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 9606438 Medline TA: Blood Press Monit Country: England |
Other Details:
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Languages: eng Pagination: 57-61 Citation Subset: IM |
Affiliation:
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Department of Psychiatry, University of California, San Diego, La Jolla, California, USA. pmills@ucsd.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Blood Pressure / drug effects Blood Pressure Monitoring, Ambulatory* Circadian Rhythm / drug effects Drug Therapy, Combination Estrogen Replacement Therapy / adverse effects Female Hormone Replacement Therapy / adverse effects* Humans Middle Aged Postmenopause / physiology* Smoking Sodium / urine |
| Grant Support | |
ID/Acronym/Agency:
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AG-13332/AG/NIA NIH HHS; HL-57265/HL/NHLBI NIH HHS; M01-RR00827/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
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7440-23-5/Sodium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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