Document Detail


Hormone replacement therapy does not affect 24-h ambulatory blood pressure in healthy non-smoking postmenopausal women.
MedLine Citation:
PMID:  12819556     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: Controversies surrounding the physiological effects of hormone replacement therapy (HRT) currently lie at the forefront of medicine. Important interindividual factors that affect blood pressure, such as smoking, body mass and sodium intake, may account for the conflicting findings seen in studies examining the effects of HRT on blood pressure. DESIGN: The study was a randomized, double-blind, placebo-controlled trial. METHODS: The effect of combination HRT and estrogen-only replacement therapy (ERT) on ambulatory blood pressure was examined in a sample of 46 healthy, normotensive, non-smoking, non-obese postmenopausal women between 45 and 65 years of age. Twenty-four hour urinary sodium excretion was examined prior to and following treatment. The women were randomized to 3 months' treatment with HRT, ERT or placebo. RESULTS: After treatment, there were no significant effects of either HRT or ERT on daytime or night-time systolic or diastolic blood pressure. Sodium excretion was similar across the groups. There were no effects of treatment on night-time blood pressure dipping. CONCLUSIONS: The findings from this prospective treatment study support the conclusion that HRT has no significant effect on daytime or night-time blood pressure in a sample of healthy, non-smoking postmenopausal women.
Authors:
Paul J Mills; Noha H Farag; Scott Matthews; Richard A Nelesen; Charles C Berry; Joel E Dimsdale
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Blood pressure monitoring     Volume:  8     ISSN:  1359-5237     ISO Abbreviation:  Blood Press Monit     Publication Date:  2003 Apr 
Date Detail:
Created Date:  2003-06-23     Completed Date:  2004-02-20     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  9606438     Medline TA:  Blood Press Monit     Country:  England    
Other Details:
Languages:  eng     Pagination:  57-61     Citation Subset:  IM    
Affiliation:
Department of Psychiatry, University of California, San Diego, La Jolla, California, USA. pmills@ucsd.edu
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MeSH Terms
Descriptor/Qualifier:
Aged
Blood Pressure / drug effects
Blood Pressure Monitoring, Ambulatory*
Circadian Rhythm / drug effects
Drug Therapy, Combination
Estrogen Replacement Therapy / adverse effects
Female
Hormone Replacement Therapy / adverse effects*
Humans
Middle Aged
Postmenopause / physiology*
Smoking
Sodium / urine
Grant Support
ID/Acronym/Agency:
AG-13332/AG/NIA NIH HHS; HL-57265/HL/NHLBI NIH HHS; M01-RR00827/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
7440-23-5/Sodium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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