Document Detail


Hormone release is tied to changes in cell size in the osmoreceptive prolactin cell of a euryhaline teleost fish, the tilapia, Oreochromis mossambicus.
MedLine Citation:
PMID:  15242746     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Prolactin (PRL) cells from a teleost fish, the tilapia, Oreochromis mossambicus, facilitate the direct study of osmoreception. The release of two prolactins, PRL(188) and PRL(177), which act in freshwater osmoregulation in teleost fish, rises in vitro within 5 min after extracellular osmolality falls. An increase in cell size accompanied this rise. Cell size and PRL release also increased, albeit more slowly, following the partial replacement of medium NaCl (55 mOsmolal) with an equivalent concentration of urea, a membrane-permeant molecule. Similar replacement using mannitol, which is membrane-impermeant, elicits no response. These findings suggest that osmoreception is linked to changes in cell volume rather than to extracellular osmolality per se.
Authors:
Gregory M Weber; Andre P Seale; N Harold Richman III; M H Stetson; Tetsuya Hirano; E Gordon Grau
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  General and comparative endocrinology     Volume:  138     ISSN:  0016-6480     ISO Abbreviation:  Gen. Comp. Endocrinol.     Publication Date:  2004 Aug 
Date Detail:
Created Date:  2004-07-09     Completed Date:  2005-01-13     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370735     Medline TA:  Gen Comp Endocrinol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  8-13     Citation Subset:  IM    
Affiliation:
Hawaii Institute of Marine Biology, University of Hawaii, PO Box 1346, Coconut Island, Kaneohe, HI 96744, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Cell Size
Diuretics, Osmotic / pharmacology
Hormones / metabolism*
Male
Mannitol / pharmacology
Osmolar Concentration
Perfusion
Pituitary Gland / cytology*,  metabolism*
Prolactin / metabolism*
Rats
Sodium Chloride / pharmacology
Tilapia / metabolism*
Water-Electrolyte Balance / physiology*
Chemical
Reg. No./Substance:
0/Diuretics, Osmotic; 0/Hormones; 69-65-8/Mannitol; 7647-14-5/Sodium Chloride; 9002-62-4/Prolactin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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