| Hormone receptors in male breast carcinoma. | |
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MedLine Citation:
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PMID: 6270468 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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It is well established that approximately 60% of female breast cancers contain estrogen receptors (ER+). The hormonal receptor status of male breast cancers remains relatively unknown. Tumor tissue from 14 patients has been reviewed at the University of Oregon Health Sciences Center. Specimens of all 14 patients were ER+ with a range of 5.5 to 374 fmol/mg protein. Eight of 12 patients had tumors which also contained progesterone receptors (PR+) with a range of 42 to 1852 fmol/mg protein. Nine patients were treated by modified radical mastectomy, two by radical mastectomy, one by simple mastectomy, and two by biopsies only. Twelve patients remain free of disease with a mean follow-up of less than 2 years. The two patients who developed metastases both responded to endocrine ablation by orchiectomy and subsequent adrenalectomy. These data suggest that male breast cancer is highly endocrine sensitive and that endocrine ablation can play an integral part in those men unfortunate enough to develop disseminated disease. |
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Authors:
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S J Ruff; J E Bauer; E J Keenan; H S Moseley; W S Fletcher |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Journal of surgical oncology Volume: 18 ISSN: 0022-4790 ISO Abbreviation: J Surg Oncol Publication Date: 1981 |
Date Detail:
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Created Date: 1981-12-21 Completed Date: 1981-12-21 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0222643 Medline TA: J Surg Oncol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 55-9 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adrenalectomy Aged Breast Neoplasms / metabolism*, therapy Carcinoma, Intraductal, Noninfiltrating / metabolism*, therapy Castration Humans Male Mastectomy Middle Aged Receptors, Estrogen / analysis* Receptors, Progesterone / analysis* |
| Grant Support | |
ID/Acronym/Agency:
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PHS R10 CA21116/CA/NCI NIH HHS; PHS RR-334/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Receptors, Estrogen; 0/Receptors, Progesterone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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