Document Detail


Hormone production in the hypophysial pars tuberalis of intact and hypophysectomized rats.
MedLine Citation:
PMID:  6401246     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The endocrine function of the hypophysial pars tuberalis is currently unknown. Recent immunocytochemical and electron microscopic studies have shown the presence of gonadotropin-producing cells in this tissue in intact rats. Because the pars tuberalis is not destroyed by hypophysectomy, the objective of the present study was to determine whether this gland is activated to produce pituitary hormones following hypophysectomy. Hormone-producing cells were identified by the unlabeled antibody peroxidase-antiperoxidase method of immunocytochemistry using primary antisera generated against the following hormones: LH, FSH, TSH, GH, PRL, ACTH, and beta-endorphin. In intact control rats, the only cell types detected in the pars tuberalis were gonadotropes and thyrotropes. Most gonadotropes contained both LH and FSH. The TSH cells were a separate cell population, and constituted the majority of pars tuberalis parenchymal cells. As early as 1 week after hypophysectomy, a hyperplastic and hypertrophic response was noted in the gonadotropes, and both cell types showed cytological features characteristic of enhanced hormonal synthesis and secretion. These responses increased with time post hypophysectomy. Secretory cell types not present in the pars tuberalis before hypophysectomy, i.e. somatotropes, mammotropes, opiocorticotrophes, were not activated or induced to differentiate after hypophysectomy. Based on these immunocytochemical observations, the hypophysectomized rat cannot be viewed as an animal totally devoid of anterior pituitary hormones. It has the capacity, or at least the potential, for secretion of LH, FSH, and TSH.
Authors:
D S Gross
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Endocrinology     Volume:  112     ISSN:  0013-7227     ISO Abbreviation:  Endocrinology     Publication Date:  1983 Feb 
Date Detail:
Created Date:  1983-02-25     Completed Date:  1983-02-25     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0375040     Medline TA:  Endocrinology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  733-44     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Follicle Stimulating Hormone / analysis
Hypophysectomy
Luteinizing Hormone / analysis
Median Eminence / cytology
Pituitary Gland / analysis,  cytology*
Rats
Rats, Inbred Strains
Thyrotropin / analysis
Grant Support
ID/Acronym/Agency:
HD-16882/HD/NICHD NIH HHS
Chemical
Reg. No./Substance:
9002-67-9/Luteinizing Hormone; 9002-68-0/Follicle Stimulating Hormone; 9002-71-5/Thyrotropin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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