| Hormone levels and cognitive function in postmenopausal midlife women. | |
| | |
MedLine Citation:
|
PMID: 22607736 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
Gonadal hormones may influence cognitive function. Postmenopausal midlife women in the population-based Melbourne Women's Midlife Health Project cohort were administered a comprehensive battery of neuropsychological tests on two occasions 2 years apart. Participants (n = 148, mean age 60 years) had undergone natural menopause and were not using hormone therapy. Estrone, total and free estradiol, and total and free testosterone levels were measured at time of the first testing. Principal-component analysis identified four cognitive factors. In multiple linear regression analyses, better semantic memory performance was associated with higher total (p = 0.02) and free (p = 0.03) estradiol levels and a lower ratio of testosterone to estradiol (p = 0.007). There were trends for associations between better verbal episodic memory and lower total testosterone (p = 0.08) and lower testosterone/estradiol ratio (p = 0.06). Lower free testosterone levels were associated with greater 2-year improvement on verbal episodic memory (p = 0.04); higher testosterone/estradiol predicted greater semantic memory improvement (p = 0.03). In postmenopausal midlife women, endogenous estradiol and testosterone levels and the testosterone/estradiol ratio are associated with semantic memory and verbal episodic memory abilities. |
| | |
Authors:
|
Joanne Ryan; Frank Z Stanczyk; Lorraine Dennerstein; Wendy J Mack; Margaret S Clark; Cassandra Szoeke; Daniel Kildea; Victor W Henderson |
Related Documents
:
|
22896046 - Implicit statistical learning and language skills in bilingual children. 20424036 - Wishful seeing: more desired objects are seen as closer. 22663156 - Can older adults accurately judge their learning of emotional information? 11277466 - Categorical perception of relative orientation in visual object recognition. 22285906 - Neurocognitive mechanisms of gaze-expression interactions in face processing and social... 3194046 - Handedness and manual specialization in the baboon. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Neurobiology of aging Volume: 33 ISSN: 1558-1497 ISO Abbreviation: Neurobiol. Aging Publication Date: 2012 Jul |
Date Detail:
|
Created Date: 2012-05-21 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8100437 Medline TA: Neurobiol Aging Country: United States |
Other Details:
|
Languages: eng Pagination: 1138-1147.e2 Citation Subset: IM |
Copyright Information:
|
Copyright © 2012 Elsevier Inc. All rights reserved. |
Affiliation:
|
Department of Psychiatry and National Ageing Research Institute, The University of Melbourne, Parkville 3010, Victoria, Australia; INSERM, U888, Montpellier, F-34093, France; University Montpellier 1, Montpellier, F-34000, France. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Branchial cysts within the parotid salivary gland.
Next Document: Wing flap reconstruction for large defects of the lower lip.