Document Detail

Hormone-induced delayed ovulation affects early embryonic development.
MedLine Citation:
PMID:  21474126     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To analyze the effects of delayed ovulation on embryonic development in mice, because intrafollicular oocyte development may be delayed during assisted reproductive technology (ART) treatment in humans.
DESIGN: Experimental mouse study.
SETTING: University hospital.
ANIMAL(S): Female C57Bl/6 mice.
INTERVENTION(S): Cetrorelix is used as a GnRH-antagonist in ART treatments. To assess the effect of delayed ovulation on embryonic development, cetrorelix was applied concomitantly with follicle stimulation by pregnant mare serum gonadotropin. Ovulation was induced by hCG. Controls were stimulated with pregnant mare serum gonadotropin without delaying ovulation. Suppression of ovulation was assessed from the number of tertiary follicles, ruptured follicles, and corpora lutea in mouse ovaries after cetrorelix treatment. Number and weight of embryos and placentas, as well as number of resorption sites and dead embryos, was determined on day 17.5 of pregnancy.
MAIN OUTCOME MEASURE(S): Inhibition of ovulation, embryonic development.
RESULT(S): Cetrorelix inhibited ovulation in mice, as shown by an increase in number of tertiary follicles concomitant with a significant inhibition of follicle rupture and corpora lutea formation. Delayed ovulation caused by Cetrorelix treatment led to a significant increase in resorption sites and a significant decrease in embryonic weight of offspring.
CONCLUSION(S): Preovulatory oocyte overripeness might have an effect on fertility and embryonic development during ART treatment.
Ann-Kathrin Bittner; Bernhard Horsthemke; Elke Winterhager; Ruth Grümmer
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Publication Detail:
Type:  Journal Article     Date:  2011-04-06
Journal Detail:
Title:  Fertility and sterility     Volume:  95     ISSN:  1556-5653     ISO Abbreviation:  Fertil. Steril.     Publication Date:  2011 Jun 
Date Detail:
Created Date:  2011-05-23     Completed Date:  2011-07-28     Revised Date:  2013-05-29    
Medline Journal Info:
Nlm Unique ID:  0372772     Medline TA:  Fertil Steril     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2390-4     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.
Institute of Molecular Biology, University Hospital Essen, University Duisburg-Essen, Essen, Germany.
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MeSH Terms
Chorionic Gonadotropin / pharmacology
Dose-Response Relationship, Drug
Embryo Implantation / drug effects
Embryo Loss / chemically induced
Embryonic Development / drug effects
Fertility / drug effects
Fertility Agents, Female / adverse effects,  pharmacology*
Gestational Age
Gonadotropin-Releasing Hormone / adverse effects,  analogs & derivatives*,  antagonists & inhibitors*,  pharmacology
Gonadotropins, Equine / pharmacology
Hormone Antagonists / adverse effects,  pharmacology*
Mice, Inbred C57BL
Ovulation / drug effects*
Ovulation Induction / adverse effects,  methods*
Placenta / drug effects,  growth & development
Reproductive Techniques, Assisted*
Time Factors
Reg. No./Substance:
0/Chorionic Gonadotropin; 0/Fertility Agents, Female; 0/Gonadotropins, Equine; 0/Hormone Antagonists; 33515-09-2/Gonadotropin-Releasing Hormone; OON1HFZ4BA/cetrorelix

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