Document Detail


Hormonal variation in bitches after early or mid-pregnancy termination with aglepristone (RU534).
MedLine Citation:
PMID:  11787157     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Seven bitches in early pregnancy (12.8 +/- 3.8 days after ovulation; group 1) and seven bitches in mid-pregnancy (32.0 +/- 1.53 days after ovulation; group 2) were used in this study. For each group, five bitches were treated with 0.10 mg aglepristone (Alizine) kg-1 and this dose was repeated 24 h later. Two control bitches received a placebo. Blood samples were collected at 6 h intervals to determine plasma concentrations of progesterone, dihydro-keto prostaglandin F2 alpha (PGFM), oxytocin, prolactin and cortisol. Parturition occurred in the four control bitches. All bitches treated with aglepristone aborted. In group 1, embryonic death occurred; in group 2, fetal expulsion occurred 60-132 h after administration of aglepristone. After pregnancy termination, the interoestrous interval of aglepristone-treated bitches was significantly shorter than that before treatment. Treatment with aglepristone did not modify plasma concentrations of progesterone, prostaglandin, oxytocin or cortisol within 24 h after its administration, but it induced, in mid-pregnancy (group 2) a discharge of prolactin within 12 h after its administration. As an abortifacient, aglepristone acted on the uterus and, therefore, did not have direct or immediate luteolytic properties. Termination of pregnancy occurred with high plasma progesterone concentrations. Fetal expulsion was characterized by an increase in the concentration of PGFM, but oxytocin and cortisol remained at basal concentrations.
Authors:
F Fieni; J Martal; P G Marnet; B Siliart; F Bernard; M Riou; J F Bruyas; D Tainturier
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Journal of reproduction and fertility. Supplement     Volume:  57     ISSN:  0449-3087     ISO Abbreviation:  J. Reprod. Fertil. Suppl.     Publication Date:  2001  
Date Detail:
Created Date:  2002-01-11     Completed Date:  2002-02-19     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0225652     Medline TA:  J Reprod Fertil Suppl     Country:  England    
Other Details:
Languages:  eng     Pagination:  243-8     Citation Subset:  IM    
Affiliation:
Laboratory of Biotechnology and Pathology of Reproduction, National Veterinary School, BP 40706, 44307 Nantes, France.
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MeSH Terms
Descriptor/Qualifier:
Abortifacient Agents / administration & dosage*
Abortion, Induced / veterinary*
Abortion, Veterinary*
Animals
Dinoprost / analogs & derivatives*,  blood
Dogs
Estrenes / administration & dosage*
Female
Gestational Age
Hormones / blood*
Hydrocortisone / blood
Oxytocin / blood
Pregnancy
Progesterone / antagonists & inhibitors*,  blood
Prolactin / blood
Random Allocation
Chemical
Reg. No./Substance:
0/Abortifacient Agents; 0/Estrenes; 0/Hormones; 124478-60-0/aglepristone; 27376-76-7/15-keto-13,14-dihydroprostaglandin F2alpha; 50-23-7/Hydrocortisone; 50-56-6/Oxytocin; 551-11-1/Dinoprost; 57-83-0/Progesterone; 9002-62-4/Prolactin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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