Document Detail

Hormonal treatment in pregnancy: a possible risk factor for neuroblastoma.
MedLine Citation:
PMID:  8202036     Owner:  NLM     Status:  MEDLINE    
In the last 4 years, 24 cases of neuroblastoma were treated in the Pediatric Hematology-Oncology Unit at the Chaim Sheba Medical Center, 8 of whom were under 1 year of age. Four of them were the product of a pregnancy-induced or preserved by gonadotropins, clomiphene citrate, or progestational hormones. These drugs are known to produce a higher than normal level of estradiol or progesterone in the early stages of pregnancy. Our observation led to the hypothesis that high levels of progestational hormones given during pregnancy are a risk factor for neuroblastoma in infancy.
M Mandel; A Toren; G Rechavi; J Dor; I Ben-Bassat; Y Neumann
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Medical and pediatric oncology     Volume:  23     ISSN:  0098-1532     ISO Abbreviation:  Med. Pediatr. Oncol.     Publication Date:  1994  
Date Detail:
Created Date:  1994-07-06     Completed Date:  1994-07-06     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7506654     Medline TA:  Med Pediatr Oncol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  133-5     Citation Subset:  IM    
Institute of Hematology, Chaim Sheba Medical Center, Tel-Hashomer, Israel.
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MeSH Terms
Chorionic Gonadotropin / adverse effects*
Neuroblastoma / etiology*
Pregnancy Complications / drug therapy
Pregnancy Trimester, First / drug effects
Prenatal Exposure Delayed Effects*
Progestins / adverse effects*
Reg. No./Substance:
0/Chorionic Gonadotropin; 0/Progestins; 145-14-2/20-alpha-Dihydroprogesterone; 25614-03-3/Bromocriptine; 911-45-5/Clomiphene

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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