Document Detail

Hormonal supply during physical exercise in elderly patients with ischemic heart disease.
MedLine Citation:
PMID:  2838399     Owner:  NLM     Status:  MEDLINE    
30 males, suffering from ischemic heart disease (IHD), and stable exertional angina pectoris, whose age ranged from 60 to 74 years and also 15 apparently healthy volunteers of the same age participated in the study. The IHD patients' blood displayed increased basal levels of adrenocorticotropic hormone (ACTH), cortisol, and met-enkephalins. During graded physical exercise two types of hormonal system response were established: in the first group of patients the plasma ACTH and cortisol levels were seen to rise at maximal threshold load, while in the second group the content of the above hormones declined. The first group of patients showed a less economical hemodynamic response to standard loading in comparison to the second group. A relation was found between changes in hemodynamic system and function of pituitary-adrenal system in elderly IHD patients during physical exercise. Inadequate ACTH and cortisol increase in the course of effects of stress contributed to IHD aggravation in old age, along with reduced tolerance to physical exercise. beta-Adrenoblocker, propranolol, influenced both types of hormonal response, thereby diminishing their shifts in physical stress.
O V Korkushko; M V Frolkis; Y T Yaroshenko
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Gerontology     Volume:  34     ISSN:  0304-324X     ISO Abbreviation:  Gerontology     Publication Date:  1988  
Date Detail:
Created Date:  1988-07-29     Completed Date:  1988-07-29     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  7601655     Medline TA:  Gerontology     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  88-94     Citation Subset:  IM    
Institute of Gerontology AMS USSR, Kiev.
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MeSH Terms
Adrenocorticotropic Hormone / blood
Aldosterone / blood
Coronary Disease / blood*,  physiopathology
Endorphins / blood
Exercise Test
Hemodynamics / drug effects
Hormones / blood*
Hydrocortisone / blood
Hypothalamo-Hypophyseal System / physiopathology
Middle Aged
Oxygen Consumption
Physical Exertion*
Pituitary-Adrenal System / physiopathology
Propranolol / pharmacology
Stress, Physiological / blood*,  physiopathology
Reg. No./Substance:
0/Endorphins; 0/Hormones; 50-23-7/Hydrocortisone; 52-39-1/Aldosterone; 525-66-6/Propranolol; 9002-60-2/Adrenocorticotropic Hormone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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