| Hormonal responses in elders experiencing pre-syncopal symptoms during head-up tilt before and after exercise training. | |
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MedLine Citation:
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PMID: 7583804 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Hormonal responses of elderly individuals experiencing pre-syncopal symptoms during head-up tilt testing (HUT) were compared with responses of nonsymptomatic subjects both before (T1) and after (T2) 6 months of endurance training. METHODS: Based on responses to HUT at T1, 35 men and women (ages 61-79 years) were placed into symptomatic and nonsymptomatic groups for analysis. Symptomatic subjects (n = 5) experienced lightheadedness, nausea, sweating, or syncope during T1 HUT but completed 15 minutes of HUT at T2. Training consisted of treadmill walking or stairclimbing 3 x/wk, 30-45 min/day, at 75-85% of maximal heart rate reserve. Adrenocorticotropic hormone (ACTH), vasopressin, aldosterone, norepinephrine, epinephrine, hemoglobin, and hematocrit were measured during supine rest prior to HUT, and either at the end of the 15-minute HUT or at symptom onset. Plasma volume (PV) was measured at supine rest; tilt-induced changes in PV were calculated from changes in hemoglobin and hematocrit. RESULTS: During T1 HUT, symptomatic subjects had greater increases in vasopressin and a greater rate of PV loss (p < .05). Increases in ACTH and aldosterone were greater in symptomatic subjects at T1 and T2, while increases in norepinephrine were greater at T2 (p < .05). Reductions in tilt-induced vasopressin concentration and a decreased rate of PV loss were seen at T2 in symptomatic subjects. CONCLUSIONS: T1 results from symptomatic subjects are consistent with greater stimulation of volume-sensitive receptors induced by a greater rate of fall in PV. Exercise training resulted in increased tilt tolerance for symptomatic subjects associated with reductions in vasopressin concentration and rate of PV loss during tilt. |
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Authors:
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J F Carroll; C E Wood; M L Pollock; J E Graves; V A Convertino; D T Lowenthal |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: The journals of gerontology. Series A, Biological sciences and medical sciences Volume: 50 ISSN: 1079-5006 ISO Abbreviation: J. Gerontol. A Biol. Sci. Med. Sci. Publication Date: 1995 Nov |
Date Detail:
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Created Date: 1995-12-21 Completed Date: 1995-12-21 Revised Date: 2010-03-24 |
Medline Journal Info:
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Nlm Unique ID: 9502837 Medline TA: J Gerontol A Biol Sci Med Sci Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: M324-9 Citation Subset: AIM; IM; S |
Affiliation:
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Center for Exercise Science, College of Medicine, University of Florida, Gainesville, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Aged, 80 and over Aging / blood* Blood Volume Dizziness / blood Exercise / physiology* Female Hormones / blood* Humans Male Middle Aged Nausea / blood Physical Education and Training Physical Endurance / physiology Sweating Syncope / blood* Tilt-Table Test* |
| Chemical | |
Reg. No./Substance:
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0/Hormones |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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