Document Detail


Hormonal regulators of food intake and weight gain in Parkinson's disease after subthalamic nucleus stimulation.
MedLine Citation:
PMID:  21876505     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: Weight gain has been reported in patients with Parkinson's disease (PD) treated with deep brain stimulation of the subthalamic nucleus (STN-DBS). To evaluate the influence of STN-DBS on weight changes, we studied food-related hormones.
DESIGN: Anthropometric parameters and food-related hormones (leptin, adiponectin, resistin, ghrelin, cortisol, insulin, and thyroid stimulating hormone) were measured in 27 patients with STN-DBS during a 12 month period following electrode implantation.
RESULTS: Besides marked motor improvements on STN-DBS, PD patients significantly gained weight. The mean weight gain at 12 months was 5.2±(SD)5.8 kg. A significant decrease in cortisol levels compared to baseline appeared at month 2 and persisted at 12 months (p<0.01, corrected), with no significant changes in other hormones tested.
CONCLUSIONS: Changes in peripheral food-related hormones do not appear to cause weight gain in PD patients. Direct effects of STN-DBS on hypothalamic catabolic/anabolic peptide balance remain hypothetical and necessitate further elucidation.
Authors:
Lucie Novakova; Martin Haluzik; Robert Jech; Dusan Urgosik; Filip Ruzicka; Evzen Ruzicka
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Neuro endocrinology letters     Volume:  32     ISSN:  0172-780X     ISO Abbreviation:  Neuro Endocrinol. Lett.     Publication Date:  2011  
Date Detail:
Created Date:  2011-09-14     Completed Date:  2011-10-31     Revised Date:  2012-04-09    
Medline Journal Info:
Nlm Unique ID:  8008373     Medline TA:  Neuro Endocrinol Lett     Country:  Sweden    
Other Details:
Languages:  eng     Pagination:  437-41     Citation Subset:  IM    
Affiliation:
Department of Neurology and Centre of Clinical Neuroscience, Charles University, Prague, Czech Republic.
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MeSH Terms
Descriptor/Qualifier:
Adiponectin / blood
Adult
Aged
Deep Brain Stimulation / methods*
Eating / physiology*
Female
Ghrelin / blood
Hormones / blood*
Humans
Hydrocortisone / blood
Hypothalamus / physiology
Insulin / blood
Leptin / blood
Male
Middle Aged
Parkinson Disease / metabolism*,  therapy*
Resistin / blood
Subthalamic Nucleus / physiology*
Thyrotropin / blood
Weight Gain / physiology
Chemical
Reg. No./Substance:
0/ADIPOQ protein, human; 0/Adiponectin; 0/Ghrelin; 0/Hormones; 0/Insulin; 0/Leptin; 0/RETN protein, human; 0/Resistin; 50-23-7/Hydrocortisone; 9002-71-5/Thyrotropin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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