| Hormonal regulation of the tricarboxylic acid cycle in the isolated perfused rat liver. | |
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MedLine Citation:
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PMID: 3091366 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effect of Ca2+-mobilizing hormones, vasopressin, angiotensin II and the alpha-adrenergic agonist phenylephrine, on the metabolic flux through the tricarboxylic acid cycle was investigated in isolated perfused rat livers. All three Ca2+-mobilizing agonists stimulated 14CO2 production and gluconeogenesis in livers of 24-h-fasted rats perfused with [2-14C]pyruvate. Prazosin blocked the phenylephrine-elicited stimulation of 14CO2 and glucose production from [2-14C]pyruvate whereas the alpha 2-adrenergic agonist, BHT-933, did not affect the rates of 14CO2 and glucose production from [2-14C]pyruvate indicating that the phenylephrine-mediated response involved alpha 1-adrenergic receptors. Phenylephrine, vasopressin and angiotensin II stimulated 14CO2 production from [2-14C]acetate in livers derived from fed rats but not in livers of 24-h-fasted rats. In livers of 24-h-fasted rats, perfused with [2-14C]acetate, exogenously added pyruvate was required for an increase in the rate of 14CO2 production during phenylephrine infusion. This last observation suggests increased pyruvate carboxylation as one of the mechanisms involved in stimulation of tricarboxylic acid cycle activity by the Ca2+-mobilizing agonists, vasopressin, angiotensin II and phenylephrine. |
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Authors:
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T B Patel |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: European journal of biochemistry / FEBS Volume: 159 ISSN: 0014-2956 ISO Abbreviation: Eur. J. Biochem. Publication Date: 1986 Aug |
Date Detail:
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Created Date: 1986-10-23 Completed Date: 1986-10-23 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0107600 Medline TA: Eur J Biochem Country: GERMANY, WEST |
Other Details:
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Languages: eng Pagination: 15-22 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acetates
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metabolism Angiotensin II / pharmacology* Animals Calcium / metabolism* Carbon Dioxide / biosynthesis Citric Acid Cycle / drug effects* Gluconeogenesis / drug effects Liver / metabolism* Male Phenylephrine / pharmacology* Pyruvates / metabolism Pyruvic Acid Rats Rats, Inbred Strains Vasopressins / pharmacology* |
| Grant Support | |
ID/Acronym/Agency:
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AM 35713/AM/NIADDK NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Acetates; 0/Pyruvates; 11000-17-2/Vasopressins; 11128-99-7/Angiotensin II; 124-38-9/Carbon Dioxide; 127-17-3/Pyruvic Acid; 59-42-7/Phenylephrine; 7440-70-2/Calcium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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