Document Detail

Hormonal regulation of ovarian cellular proliferation.
MedLine Citation:
PMID:  566619     Owner:  NLM     Status:  MEDLINE    
The steroid hormone estradiol, and the glycoprotein hormones follicle-stimulating hormone (FSH) and luteinizing hormone (LH), are known to be essential for the growth and differentiation of follicles in the ovary. The present study was conducted to determine quantitatively the effects of estradiol, FSH and LH on proliferation of different ovarian cell types (granulosa and theca cells). The immature female hypophysectomized rate sequentially primed with estradiol, FSH and LH was used as the experimental model. Proliferation was assessed by examining changes in total DNA, incorporation of 3H-thymidine into DNA and labeling index in specific cell types. Estradiol and FSH each acted on follicles at different stages of development to stimulate proliferative activity of both granulosa and theca cells. Continued administration of either hormone caused a decrease in the proliferative activity of both cell types. These observations have been interpreted to indicate that estradiol and FSH can each alter the length of the specific phases of the cell cycle. A luteinizing dose of LH caused a cessation of proliferation in luteinizing granulosa cells while stimulating a limited proliferation of theca cells. Absence of the appropriate hormonal stimulus caused both granulosa and theca cells to stop proliferating and the follicles to undergo atresia. These results indicate that, depending upon the state of differentiation of granulosa and theca cells, estradiol, FSH and LH can stimulate or inhibit the ability of these cells to proliferate.
M C Rao; A R Midgley; J S Richards
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Cell     Volume:  14     ISSN:  0092-8674     ISO Abbreviation:  Cell     Publication Date:  1978 May 
Date Detail:
Created Date:  1978-09-25     Completed Date:  1978-09-25     Revised Date:  2002-11-01    
Medline Journal Info:
Nlm Unique ID:  0413066     Medline TA:  Cell     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  71-8     Citation Subset:  IM    
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MeSH Terms
Cell Division / drug effects
DNA / biosynthesis
Estradiol / pharmacology*
Follicle Stimulating Hormone / pharmacology*
Granulosa Cells / cytology,  drug effects*
Luteinizing Hormone / pharmacology*
Theca Cells / cytology,  drug effects*
Reg. No./Substance:
50-28-2/Estradiol; 9002-67-9/Luteinizing Hormone; 9002-68-0/Follicle Stimulating Hormone; 9007-49-2/DNA

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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