| Hormonal regulation of gastric acid secretion. | |
| | |
MedLine Citation:
|
PMID: 19006605 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Although gastric acid is not essential for life, it facilitates the digestion of protein and the absorption of iron, calcium, vitamin B(12), and thyroxin. It also prevents bacterial overgrowth and enteric infection. Gastric acid secretion must be precisely regulated, as too much acid may overwhelm mucosal defense mechanisms and lead to ulceration and maldigestion. The pathways regulating gastric acid secretion may be categorized as neural, paracrine, and hormonal; the hormonal pathways are the focus of this review. During meal ingestion, the main hormone responsible for stimulating acid secretion is gastrin, which acts primarily by releasing histamine from enterochromaffin-like cells. Ghrelin and orexin may also function as stimulatory hormones. Nutrients within the intestine, mainly lipid and protein, release peptide hormones such as cholecystokinin, secretin, neurotensin, and glucagon-like peptide, which may act in concert to inhibit acid secretion. |
| | |
Authors:
|
Mitchell L Schubert |
Related Documents
:
|
8528285 - Expression of a single-chain fv antibody against abscisic acid creates a wilty phenotyp... 1647685 - Hormonal mediators of amino acid-induced glomerular hyperfiltration in humans. 3714365 - Thyroid hormone opposes some glucocorticoid effects on glycogen content and lipid synth... 163105 - Stimulation of cartilage amino acid uptake by growth hormone-dependent factors in serum... 14693505 - Inhibition of acid secretion by the nonsteroidal anti-inflammatory drugs diclofenac and... 9008355 - Calcium and phosphorous deficiencies alter the lipid composition and fluidity of intest... |
Publication Detail:
|
Type: Journal Article; Review |
Journal Detail:
|
Title: Current gastroenterology reports Volume: 10 ISSN: 1534-312X ISO Abbreviation: Curr Gastroenterol Rep Publication Date: 2008 Dec |
Date Detail:
|
Created Date: 2008-11-13 Completed Date: 2009-03-03 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 100888896 Medline TA: Curr Gastroenterol Rep Country: United States |
Other Details:
|
Languages: eng Pagination: 523-7 Citation Subset: IM |
Affiliation:
|
McGuire Veterans Affairs Medical Center, Code 111N, Gastroenterology Division, 1201 Broad Rock Boulevard, Richmond, VA 23249, USA. Mitchell.Schubert@va.gov |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Gastric Acid / secretion* Gastrins / physiology* Gastrointestinal Hormones / physiology* Ghrelin / physiology Humans Intracellular Signaling Peptides and Proteins / physiology Neuropeptides / physiology Stomach / cytology, physiology* |
| Chemical | |
Reg. No./Substance:
|
0/Gastrins; 0/Gastrointestinal Hormones; 0/Ghrelin; 0/Intracellular Signaling Peptides and Proteins; 0/Neuropeptides; 0/orexins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: LYMFASIM, a simulation model for predicting the impact of lymphatic filariasis control: quantificati...
Next Document: Pharmacology of proton pump inhibitors.