| Hormonal regulation of gastric acid in peptic ulcer disease. | |
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MedLine Citation:
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PMID: 2906469 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Although the pathogenetic role of gastrin in gastric acid hypersecretion and peptic ulcer is well established in a number of uncommon disorders, such as Zollinger-Ellison syndrome, antral G-cell hyperfunction, and retained, excluded antrum after subtotal gastrectomy, the significance of hormonal abnormalities in normogastrinaemic peptic ulcer is less obvious. Most studies have pointed to an impaired feedback mechanism between gastric acid and antral gastrin secretion in duodenal ulcer disease, possibly due to antral somatostatin deficiency. Furthermore, antisecretory drugs may induce abnormalities of gastrointestinal hormones. Potent antisecretory drugs, such as omeprazole, increase serum and antral gastrin and reduce antral somatostatin, whereas certain prostaglandin E2 analogues inhibit serum gastrin secretion after feeding. |
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Authors:
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C B Lamers |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Scandinavian journal of gastroenterology. Supplement Volume: 146 ISSN: 0085-5928 ISO Abbreviation: Scand. J. Gastroenterol. Suppl. Publication Date: 1988 |
Date Detail:
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Created Date: 1989-04-05 Completed Date: 1989-04-05 Revised Date: 2008-02-13 |
Medline Journal Info:
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Nlm Unique ID: 0437034 Medline TA: Scand J Gastroenterol Suppl Country: NORWAY |
Other Details:
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Languages: eng Pagination: 5-10 Citation Subset: IM |
Affiliation:
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Dept. Gastroenterology-Hepatology, University Hospital, Leiden, The Netherlands. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Anti-Ulcer Agents / therapeutic use* Feedback Gastric Acid / secretion* Gastrins / secretion* Humans Peptic Ulcer / drug therapy, metabolism* Somatostatin / physiology* |
| Chemical | |
Reg. No./Substance:
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0/Anti-Ulcer Agents; 0/Gastrins; 51110-01-1/Somatostatin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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