Document Detail

Hormonal regulation of female proceptivity and its influence on male sexual preference in rats.
MedLine Citation:
PMID:  6364188     Owner:  NLM     Status:  MEDLINE    
Two experiments were conducted that assessed the effect of varying levels of female proceptive/attractive behaviors on male sexual preferences in sexually experienced rats. In Experiment 1, adult ovariectomized Sprague-Dawley rats were brought into behavioral estrus by a combination of estradiol-17 beta-benzoate (EB) (4 micrograms) and progesterone (500 micrograms). In addition, females received an injection of either the anti-estrogen CI-628 (1 mg) or the control vehicle (10% ethanol) only. In tests for sexual responsiveness, CI-628 caused a 3 to 4 fold decline in proceptive behavior along with a small but significant decline in receptivity. When individual males were placed in a testing arena with a pair of receptive females, only one of which received CI-628, males displayed a preference for the control-group females, as measured by overall copulatory rate. However, males did not display a consistent preference towards females of either treatment, as measured by choice of female for ejaculation. Similarly, there were no significant correlations between female proceptive behaviors and either overall copulatory rate or ejaculation. In Experiment 2, females came into behavioral estrus after being given four daily injections of EB followed by either a single injection of progesterone or just the oil vehicle. The absence of progesterone caused a significant decline in receptivity and almost entirely eliminated proceptive behaviors. When males were tested with a pair of females, only one of which received progesterone, males preferred the progesterone-injected female as measured by overall copulatory rate. However, similar to Experiment 1, no consistent preferences were evident when measured by using choice of female for ejaculation.(ABSTRACT TRUNCATED AT 250 WORDS)
I T Landau; J E Madden
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Physiology & behavior     Volume:  31     ISSN:  0031-9384     ISO Abbreviation:  Physiol. Behav.     Publication Date:  1983 Nov 
Date Detail:
Created Date:  1984-03-12     Completed Date:  1984-03-12     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0151504     Medline TA:  Physiol Behav     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  679-85     Citation Subset:  IM    
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MeSH Terms
Estradiol / pharmacology*
Nitromifene / pharmacology
Progesterone / pharmacology*
Rats, Inbred Strains
Sexual Behavior, Animal / drug effects*
Reg. No./Substance:
10448-84-7/Nitromifene; 50-28-2/Estradiol; 57-83-0/Progesterone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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