Document Detail

Hormonal regulation of the arcuate nucleus melanocortin system.
MedLine Citation:
PMID:  17485318     Owner:  NLM     Status:  MEDLINE    
Over the past century, the hypothalamus has emerged as one of the critical sites involved in energy homeostasis. Degeneration studies in rats performed some six decades ago, first led to identifying hypothalamic subregions controlling food intake and body weight. The idea that the central nervous system (CNS), and the hypothalamus in particular, are key in metabolism regulation was reinforced by the discovery of leptin in 1994. Since the identification of leptin, enormous progress has been made in the understanding of the regulation of hypothalamic and extrahypothalamic brain regions that control food intake and energy expenditure by peripheral signals such as hormones. An important challenge is to decipher these complicated interactions between peripheral signals and neuronal circuits to better understand the etiology of metabolic disorders and to identify opportunities to intervene with pharmacological treatment. In this review, we focus on the hormonal regulation of the neuronal circuits of the arcuate nucleus of the hypothalamus: the melanocortin system.
Anna Coppola; Sabrina Diano
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review     Date:  2007-05-01
Journal Detail:
Title:  Frontiers in bioscience : a journal and virtual library     Volume:  12     ISSN:  1093-4715     ISO Abbreviation:  Front. Biosci.     Publication Date:  2007  
Date Detail:
Created Date:  2007-05-08     Completed Date:  2007-06-29     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9709506     Medline TA:  Front Biosci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  3519-30     Citation Subset:  IM    
Dept of Obstetrics, Gynecology & Reproductive Sciences, Yale University School of Medicine, New Haven, CT 06511, USA.
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MeSH Terms
Arcuate Nucleus / physiology*
Energy Metabolism
Glucocorticoids / physiology
Insulin / physiology
Leptin / physiology
Melanocortins / physiology*
Melatonin / physiology*
Peptide Hormones / physiology
Thyroid Hormones / physiology
Grant Support
Reg. No./Substance:
0/Ghrelin; 0/Glucocorticoids; 0/Leptin; 0/Melanocortins; 0/Peptide Hormones; 0/Thyroid Hormones; 11061-68-0/Insulin; 73-31-4/Melatonin

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