| Hormonal regulation of the arcuate nucleus melanocortin system. | |
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MedLine Citation:
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PMID: 17485318 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Over the past century, the hypothalamus has emerged as one of the critical sites involved in energy homeostasis. Degeneration studies in rats performed some six decades ago, first led to identifying hypothalamic subregions controlling food intake and body weight. The idea that the central nervous system (CNS), and the hypothalamus in particular, are key in metabolism regulation was reinforced by the discovery of leptin in 1994. Since the identification of leptin, enormous progress has been made in the understanding of the regulation of hypothalamic and extrahypothalamic brain regions that control food intake and energy expenditure by peripheral signals such as hormones. An important challenge is to decipher these complicated interactions between peripheral signals and neuronal circuits to better understand the etiology of metabolic disorders and to identify opportunities to intervene with pharmacological treatment. In this review, we focus on the hormonal regulation of the neuronal circuits of the arcuate nucleus of the hypothalamus: the melanocortin system. |
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Authors:
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Anna Coppola; Sabrina Diano |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review Date: 2007-05-01 |
Journal Detail:
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Title: Frontiers in bioscience : a journal and virtual library Volume: 12 ISSN: 1093-4715 ISO Abbreviation: Front. Biosci. Publication Date: 2007 |
Date Detail:
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Created Date: 2007-05-08 Completed Date: 2007-06-29 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9709506 Medline TA: Front Biosci Country: United States |
Other Details:
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Languages: eng Pagination: 3519-30 Citation Subset: IM |
Affiliation:
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Dept of Obstetrics, Gynecology & Reproductive Sciences, Yale University School of Medicine, New Haven, CT 06511, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Arcuate Nucleus / physiology* Energy Metabolism Ghrelin Glucocorticoids / physiology Humans Insulin / physiology Leptin / physiology Melanocortins / physiology* Melatonin / physiology* Peptide Hormones / physiology Rats Thyroid Hormones / physiology |
| Grant Support | |
ID/Acronym/Agency:
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DK061619/DK/NIDDK NIH HHS; DK070039/DK/NIDDK NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Ghrelin; 0/Glucocorticoids; 0/Leptin; 0/Melanocortins; 0/Peptide Hormones; 0/Thyroid Hormones; 11061-68-0/Insulin; 73-31-4/Melatonin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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