Document Detail


Hormonal regulation of androgen-binding protein in lamb testes.
MedLine Citation:
PMID:  6774039     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Androgen-binding protein (ABP) was measured in the testes of 50-day-old lambs. The animals were hypophysectomized and treatment lasting for 5 days was begun 15 days after surgery. In hypophysectomized but otherwise untreated lambs (control group), no 5 alpha-dihydrotestosterone binding was detectable in testicular cytosol. One out of four lambs gave a positive response with FSH treatment (25 fmol ABP/mg protein), whereas a restoration of the synthesis of ABP was noted in all LH-treated animals (19 +/- 9 (S.E.M.) fmol ABP/mg, n = 4). No synergism between the two gonadotrophins was observed in lambs treated simultaneously with FSH and LH (19 +/- 4 fmol ABP/mg, n = 5). Testosterone treatment elicited a greater response (37 +/- 9 fmol ABP/mg, n = 5) than FSH or LH alone and the response was not increased by the simultaneous addition of FSH (38 +/- 10 fmol ABP/mg, n = 5). Whatever the treatment, no influence was observed either on the number of supporting cells (undifferentiated Sertoli cells) or the length of the seminiferous tubules (P>0.05); the diameter of tubules was significantly increased in the group treated with FSH and LH. It is postulated that testosterone may have a direct effect on the production of ABP by the supporting cells of the impuberal lamb.
Authors:
S Carreau; M A Drosdowsky; C Pisselet; M Courot
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of endocrinology     Volume:  85     ISSN:  0022-0795     ISO Abbreviation:  J. Endocrinol.     Publication Date:  1980 Jun 
Date Detail:
Created Date:  1980-11-25     Completed Date:  1980-11-25     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0375363     Medline TA:  J Endocrinol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  443-8     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Androgen-Binding Protein / metabolism*
Animals
Carrier Proteins / metabolism*
Cytosol / metabolism
Follicle Stimulating Hormone / pharmacology
Hypophysectomy
Luteinizing Hormone / pharmacology
Male
Organ Size / drug effects
Sheep
Testis / anatomy & histology,  drug effects,  metabolism*
Testosterone / pharmacology
Chemical
Reg. No./Substance:
0/Androgen-Binding Protein; 0/Carrier Proteins; 58-22-0/Testosterone; 9002-67-9/Luteinizing Hormone; 9002-68-0/Follicle Stimulating Hormone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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