Document Detail

Hormonal regulation of adult partner preference behavior in neonatally ATD-treated male rats.
MedLine Citation:
PMID:  8329137     Owner:  NLM     Status:  MEDLINE    
Male rats, neonatally treated with ATD (1,4,6-androstatriene-3,17-dione), which blocks the aromatization of testosterone into estradiol (E2), were tested for adult partner preference behavior (PPB; estrous female vs. active male). Castration caused a decrease in preference for the female partner in all males, with ATD males showing lower preference for the female partner than controls. Long-term castrated males did not show preference for either partner. Precastration levels of PPB in control males occurred after treatment with E2 or dihydrotestosterone (DHT) plus E2. DHT alone had no effect on PPB. With E2 alone, the ATD males clearly preferred the male partner. When DHT was added, these ATD males showed no preference for either partner or a low preference for the female partner. In conclusion, adult PPB in male rats is activated by endogenous testosterone or by both its metabolites (DHT and E2) or by E2 alone. ATD males showed a much lower preference for the female. There was a differential effect of DHT and E2: DHT had no effect, but E2 clearly caused ATD males to prefer the male partner and control males to prefer the female partner.
J Bakker; T Brand; J van Ophemert; A K Slob
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Behavioral neuroscience     Volume:  107     ISSN:  0735-7044     ISO Abbreviation:  Behav. Neurosci.     Publication Date:  1993 Jun 
Date Detail:
Created Date:  1993-08-13     Completed Date:  1993-08-13     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8302411     Medline TA:  Behav Neurosci     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  480-7     Citation Subset:  IM    
Department of Endocrinology and Reproduction, Faculty of Medicine and Health Sciences, Erasmus University, Rotterdam, The Netherlands.
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MeSH Terms
Androstatrienes / pharmacology*
Dihydrotestosterone / pharmacology
Estradiol / pharmacology
Rats, Wistar
Sexual Behavior, Animal / drug effects*
Sexual Maturation / drug effects
Social Environment
Testosterone / physiology*
Reg. No./Substance:
0/Androstatrienes; 50-28-2/Estradiol; 521-18-6/Dihydrotestosterone; 58-22-0/Testosterone; 633-35-2/androsta-1,4,6-triene-3,17-dione

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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