| Hormonal postcoital contraception with an ethinylestradiol-norgestrel combination and two danazol regimens. | |
| | |
MedLine Citation:
|
PMID: 2227068 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The ethinylestradiol-norgestrel combination (EE-NG) for postcoital contraception, as described by Yuzpe, has been shown to be an effective method but with frequent side effects. To overcome the problem of adverse effects a new approach using danazol was proposed, but the efficacy and acceptability of this treatment have not yet been tested in large studies. In a 5-year period at the AIECS Family Planning Centre in Milan we treated 2448 women requesting postcoital contraception using Yuzpe's regimen and two danazol regimens (800 mg/1200 mg). The patients' acceptability for danazol treatment was higher than for Yuzpe's regimen due to fewer, milder and shorter side effects. Nine pregnancies occurred in the EE-NG group (2.21%), 17 in the 800 mg group (1.71%) and 6 in the 1200 mg group (0.82%). Our study shows a statistically significant efficacy against expected pregnancy rates both with Yuzpe's regimen and with danazol. The 1200 mg danazol treatment seems to be more effective and can be considered a valid alternative to the EE-NG combination for hormonal postcoital contraception. The ethinyl estradiol-norgestrel combination (EE-NG) for postcoital contraception as described by Yuzpe has been shown to be an effective method but with frequent side effects. To overcome the problem of adverse effects, a new approach using danazol was proposed, but the efficacy and acceptability of this treatment has not yet been put to the test in larger groups. In a 5-year period at the AIECS Family Planning Center in Milan, the authors treated 2448 women requesting postcoital contraceptives using Yuzpe's regimen and 2 danazol regimens (800 mg/1200 mg). The danazol treatment met with a greater measure of patient acceptability than did Yuzpe's regimen, due mainly to the smaller number of side effects. 9 pregnancies occurred in the EE-NG group (2.21%), 17 in the 800 mg group (1.71%), and 6 in the 1200 mg group (0.82%). This study shows a statistically significant efficacy against expected pregnancy rates, both with Yuzpe's regimen and with danazol. The 1200 mg danazol treatment seems to be more effective and can be considered a valid alternative to the EE-NG combination for hormonal postcoital contraception. |
| | |
Authors:
|
G Zuliani; U F Colombo; R Molla |
Related Documents
:
|
12972838 - Common oral manifestations during pregnancy: a review. 3021108 - Spontaneous rupture of an hepatic adenoma in pregnancy with survival of mother and fetus. 12267108 - A multicenter randomized comparative investigation of ml cu250, tcu-220c and cu7 iuds. 15495018 - Immediate postabortal insertion of intrauterine devices. 9510058 - Effects of increasing gestation, cortisol and maternal undernutrition on hypothalamic n... 8145208 - Genetic basis of prolificacy in meishan pigs. |
Publication Detail:
|
Type: Comparative Study; Journal Article |
Journal Detail:
|
Title: European journal of obstetrics, gynecology, and reproductive biology Volume: 37 ISSN: 0301-2115 ISO Abbreviation: Eur. J. Obstet. Gynecol. Reprod. Biol. Publication Date: 1990 Dec |
Date Detail:
|
Created Date: 1990-12-12 Completed Date: 1990-12-12 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0375672 Medline TA: Eur J Obstet Gynecol Reprod Biol Country: NETHERLANDS |
Other Details:
|
Languages: eng Pagination: 253-60 Citation Subset: IM; J |
Affiliation:
|
AIECS Family Planning Centre, Milan, Italy. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adolescent Adult Contraceptives, Postcoital, Hormonal* / adverse effects Danazol / administration & dosage* Drug Administration Schedule Drug Combinations Ethinyl Estradiol / administration & dosage* Female Humans Norgestrel / administration & dosage* Pregnancy |
| Chemical | |
Reg. No./Substance:
|
0/Contraceptives, Postcoital, Hormonal; 0/Drug Combinations; 17230-88-5/Danazol; 57-63-6/Ethinyl Estradiol; 6533-00-2/Norgestrel |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: The pin-hole cervical os; a small fertility problem.
Next Document: Predictive values of CA 125 antigen levels and CT scan in second-look procedures for ovarian cancer.