Document Detail


Hormonal and nutritional regulation of SCD1 gene expression.
MedLine Citation:
PMID:  20713121     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Stearoyl-CoA Desaturase 1 (SCD1) is the rate limiting enzyme catalyzing the biosynthesis of monounsaturated fatty acids preferentially from palmitoyl-CoA and stearoyl-CoA forming respectively palmitoleyl-CoA and oleyl-CoA. These monounsaturated fatty acids are the key components of triglycerides and membrane phospholipids. Studying the regulation of SCD1 is of particular interest since alterations in phospholipids composition have been implicated in a variety of diseases including cancers, diabetes and cardiovascular disorders. Furthermore, oleic acid, the main product of SCD1 reaction, is the predominant fatty acid of human adipose tissue triacylglycerols, associating SCD1 with the development of obesity and the metabolic syndrome. In light of the key role of SCD1 in general metabolism, it is not surprising to observe a very tight and complex regulation of SCD1 gene expression in response to various parameters including hormonal and nutrient factors. In this review we analyze the anatomy and index the transcription factors that have been characterized to bind the SCD1 promoter. Then we present the current knowledge on how hormones regulate SCD1 expression with a particular interest on the role of insulin and leptin. We also describe how nutrients especially polyunsaturated fatty acids and carbohydrates modulate SCD1 gene expression.
Authors:
Daniel Mauvoisin; Catherine Mounier
Publication Detail:
Type:  Journal Article; Review     Date:  2010-08-14
Journal Detail:
Title:  Biochimie     Volume:  93     ISSN:  1638-6183     ISO Abbreviation:  Biochimie     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2010-12-21     Completed Date:  2011-03-29     Revised Date:  2012-05-24    
Medline Journal Info:
Nlm Unique ID:  1264604     Medline TA:  Biochimie     Country:  France    
Other Details:
Languages:  eng     Pagination:  78-86     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 Elsevier Masson SAS. All rights reserved.
Affiliation:
Département des Sciences Biologiques, Centre de recherche BioMed, Université du Québec À Montréal, C.P. 8888, Succursale Centre-ville, Montréal, Québec, Canada.
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MeSH Terms
Descriptor/Qualifier:
Acyl Coenzyme A / biosynthesis*
Adipose Tissue / enzymology*
Animals
Gene Expression*
Gene Expression Regulation, Enzymologic* / genetics
Hormones / metabolism*
Humans
Liver / enzymology*
Membrane Proteins* / genetics,  metabolism
Metabolic Syndrome X / metabolism
Nutritional Physiological Phenomena
Obesity / metabolism
Palmitoyl Coenzyme A / biosynthesis*
Promoter Regions, Genetic / physiology*
Stearoyl-CoA Desaturase / genetics*,  metabolism
Transcription Factors / metabolism
Chemical
Reg. No./Substance:
0/Acyl Coenzyme A; 0/Hormones; 0/Membrane Proteins; 0/Transcription Factors; 1716-06-9/oleoyl-coenzyme A; 1763-10-6/Palmitoyl Coenzyme A; 362-66-3/stearoyl-coenzyme A; EC 1.14.19.1/SCD1 protein, human; EC 1.14.19.1/Stearoyl-CoA Desaturase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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