| Hormonal and nutritional regulation of SCD1 gene expression. | |
| | |
MedLine Citation:
|
PMID: 20713121 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Stearoyl-CoA Desaturase 1 (SCD1) is the rate limiting enzyme catalyzing the biosynthesis of monounsaturated fatty acids preferentially from palmitoyl-CoA and stearoyl-CoA forming respectively palmitoleyl-CoA and oleyl-CoA. These monounsaturated fatty acids are the key components of triglycerides and membrane phospholipids. Studying the regulation of SCD1 is of particular interest since alterations in phospholipids composition have been implicated in a variety of diseases including cancers, diabetes and cardiovascular disorders. Furthermore, oleic acid, the main product of SCD1 reaction, is the predominant fatty acid of human adipose tissue triacylglycerols, associating SCD1 with the development of obesity and the metabolic syndrome. In light of the key role of SCD1 in general metabolism, it is not surprising to observe a very tight and complex regulation of SCD1 gene expression in response to various parameters including hormonal and nutrient factors. In this review we analyze the anatomy and index the transcription factors that have been characterized to bind the SCD1 promoter. Then we present the current knowledge on how hormones regulate SCD1 expression with a particular interest on the role of insulin and leptin. We also describe how nutrients especially polyunsaturated fatty acids and carbohydrates modulate SCD1 gene expression. |
| | |
Authors:
|
Daniel Mauvoisin; Catherine Mounier |
Publication Detail:
|
Type: Journal Article; Review Date: 2010-08-14 |
Journal Detail:
|
Title: Biochimie Volume: 93 ISSN: 1638-6183 ISO Abbreviation: Biochimie Publication Date: 2011 Jan |
Date Detail:
|
Created Date: 2010-12-21 Completed Date: 2011-03-29 Revised Date: 2012-05-24 |
Medline Journal Info:
|
Nlm Unique ID: 1264604 Medline TA: Biochimie Country: France |
Other Details:
|
Languages: eng Pagination: 78-86 Citation Subset: IM |
Copyright Information:
|
Copyright © 2010 Elsevier Masson SAS. All rights reserved. |
Affiliation:
|
Département des Sciences Biologiques, Centre de recherche BioMed, Université du Québec À Montréal, C.P. 8888, Succursale Centre-ville, Montréal, Québec, Canada. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Acyl Coenzyme A
/
biosynthesis* Adipose Tissue / enzymology* Animals Gene Expression* Gene Expression Regulation, Enzymologic* / genetics Hormones / metabolism* Humans Liver / enzymology* Membrane Proteins* / genetics, metabolism Metabolic Syndrome X / metabolism Nutritional Physiological Phenomena Obesity / metabolism Palmitoyl Coenzyme A / biosynthesis* Promoter Regions, Genetic / physiology* Stearoyl-CoA Desaturase / genetics*, metabolism Transcription Factors / metabolism |
| Chemical | |
Reg. No./Substance:
|
0/Acyl Coenzyme A; 0/Hormones; 0/Membrane Proteins; 0/Transcription Factors; 1716-06-9/oleoyl-coenzyme A; 1763-10-6/Palmitoyl Coenzyme A; 362-66-3/stearoyl-coenzyme A; EC 1.14.19.1/SCD1 protein, human; EC 1.14.19.1/Stearoyl-CoA Desaturase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Targeting human Rad51 by specific DNA aptamers induces inhibition of homologous recombination.
Next Document: Polygonatum cyrtonema lectin induces murine fibrosarcoma L929 cell apoptosis and autophagy via block...