Document Detail


Hormonal monitoring of early pregnancy by a direct radioimmunoassay of steroid glucuronides in first morning urine.
MedLine Citation:
PMID:  6489546     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The usefulness of the direct 4-hour radioimmunoassay of estriol-16-glucuronide (E3G) and pregnanediol-3-glucuronide (P2G) in first morning urine (FMU) for establishing a prognosis of the early pregnancy outcome was evaluated in 106 patients that became pregnant. Microaliquots of FMU were serially assayed from day 3 of the conception cycle until day 80 of pregnancy. The E3G and P2G profiles of 19 pregnancies which terminated in spontaneous abortion with either a diagnosis of the blighted ovum syndrome (n = 11) or presumption of a corpus luteum/trophoblast failure (n = 8) have been compared with those of clinically normal pregnancies (n = 87). Normal pregnancies displayed typical patterns of E3G and P2G development, while variations were observed in abortive events that reflected changes of the fetoplacental unit.
Authors:
A F Mendizábal; S Quiroga; Z Farinati; M Lahoz; C Nagle
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Fertility and sterility     Volume:  42     ISSN:  0015-0282     ISO Abbreviation:  Fertil. Steril.     Publication Date:  1984 Nov 
Date Detail:
Created Date:  1984-12-18     Completed Date:  1984-12-18     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0372772     Medline TA:  Fertil Steril     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  737-40     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Abortion, Spontaneous / diagnosis
Estriol / analogs & derivatives*,  urine
Female
Humans
Pregnancy*
Pregnanediol / analogs & derivatives*,  urine
Prognosis
Radioimmunoassay
Chemical
Reg. No./Substance:
1852-49-9/pregnanediol-3 alpha-glucuronide; 26445-07-8/Pregnanediol; 28808-07-3/estriol glucuronide; 50-27-1/Estriol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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