Document Detail

Hormonal modulation of prolyl endopeptidase and dipeptidyl peptidase IV activities in the mouse uterus and ovary.
MedLine Citation:
PMID:  1357903     Owner:  NLM     Status:  MEDLINE    
Prolyl endopeptidase and dipeptidyl peptidase IV are proline-specific peptidases, and are ubiquitously distributed in various tissues in mammals. The specific activities of these peptidases in both uterus and ovary were examined in the SHN strain of mice at estrus or diestrus. A marked change in prolyl endopeptidase activity was found in the uterus and ovary in intact mice during the estrous cycle, the activity being high at estrus and low at diestrus. In ovariectomized mice, prolyl endopeptidase activity was significantly higher in the uterus treated with progesterone or estradiol than in the uterus treated with vehicle oil only or a dopamine antagonist (perphenazine) which stimulates prolactin secretion. On the other hand, notable change in dipeptidyl peptidase IV activity during the estrous cycle was found only in the uterus of intact mice. The activity was low at estrus and high at diestrus. In ovariectomized mice, the uterus exposed to estradiol showed a lower dipeptidyl peptidase IV activity than the uteri treated with progesterone, the dopamine antagonist or vehicle oil. These findings reveal that there is a close correlation between the circulating level of ovarian steroids and the activities of these proline-specific enzymes.
N Ohta; T Takahashi; T Mori; M K Park; S Kawashima; K Takahashi; H Kobayashi
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Acta endocrinologica     Volume:  127     ISSN:  0001-5598     ISO Abbreviation:  Acta Endocrinol.     Publication Date:  1992 Sep 
Date Detail:
Created Date:  1992-11-16     Completed Date:  1992-11-16     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  0370312     Medline TA:  Acta Endocrinol (Copenh)     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  262-6     Citation Subset:  IM    
Zoological Institute, Faculty of Science, University of Tokyo, Japan.
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MeSH Terms
Antigens, CD26
Dipeptidyl-Peptidases and Tripeptidyl-Peptidases / metabolism*
Estradiol / pharmacology
Estrus / metabolism
Hormones / physiology*
Mice, Inbred Strains
Ovary / enzymology*
Perphenazine / pharmacology
Progesterone / pharmacology
Serine Endopeptidases / metabolism*
Uterus / enzymology*
Reg. No./Substance:
0/Hormones; 50-28-2/Estradiol; 57-83-0/Progesterone; 58-39-9/Perphenazine; EC 3.4.14.-/Dipeptidyl-Peptidases and Tripeptidyl-Peptidases; EC, CD26; EC 3.4.21.-/Serine Endopeptidases; EC oligopeptidase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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