Document Detail

Hormonal and metabolic changes induced by an isocaloric isoproteinic ketogenic diet in healthy subjects.
MedLine Citation:
PMID:  6761185     Owner:  NLM     Status:  MEDLINE    
The effects of a 4-day isocaloric isoprotenic dietary replacement of carbohydrate by fats were studied in six healthy subjects, the experimental diet being preceded and followed by a 3-day period of balanced diet. During the ketogenic regimen, the concentrations of fat derived substrates (free fatty acids, glycerol and 3-hydroxybutyrate) rose significantly and glucose levels decreased by 16.5 +/- 3.2% (mean +/- SEM). The hormonal pattern switched towards a catabolic mode with a fall in insulin levels (-44.0 +/- 6.3%) and a rise in glucagon concentration (+39.0 +/- 10.4%). A significant fall in triiodothyronine and rise in reverse triiodothyronine were observed, while thyroxine levels remained unchanged. The average levels of the most important gluconeogenic amino acids (alanine, glutamine, glycine, serine and threonine) were reduced by 8-34% while those of the branched chain amino acids increased by more than 50%. Since these changes reproduce those observed after a few days of total fasting, we suggest that it is the carbohydrate restriction itself which is responsible for the metabolic and hormonal adaptations of brief fasting.
F Fery; P Bourdoux; J Christophe; E O Balasse
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Diabète & métabolisme     Volume:  8     ISSN:  0338-1684     ISO Abbreviation:  Diabete Metab     Publication Date:  1982 Dec 
Date Detail:
Created Date:  1983-04-07     Completed Date:  1983-04-07     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7604157     Medline TA:  Diabete Metab     Country:  FRANCE    
Other Details:
Languages:  eng     Pagination:  299-305     Citation Subset:  IM    
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MeSH Terms
Amino Acids / blood*
Blood Glucose / analysis
Dietary Carbohydrates / administration & dosage*
Dietary Fats / administration & dosage*
Dietary Proteins / administration & dosage*
Energy Intake*
Glucagon / blood
Hormones / blood*
Insulin / blood
Ketone Bodies / metabolism
Middle Aged
Thyroid Hormones / blood
Reg. No./Substance:
0/Amino Acids; 0/Blood Glucose; 0/Dietary Carbohydrates; 0/Dietary Fats; 0/Dietary Proteins; 0/Hormones; 0/Ketone Bodies; 0/Thyroid Hormones; 11061-68-0/Insulin; 9007-92-5/Glucagon

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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