| Hormonal, metabolic, and cardiovascular responses to static exercise in humans: influence of epidural anesthesia. | |
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MedLine Citation:
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PMID: 1872383 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To determine the role of reflex neural mechanisms for hormonal, metabolic, heart rate (HR), and blood pressure (MABP) changes during static exercise, seven health young males performed 10-min periods of two-legged static knee extension both during control and during epidural anesthesia. Comparisons were made at identical absolute (29 Nm) and relative [15% maximal voluntary contraction (MVC)] force. Afferent nerve blockade was verified by hypesthesia below T10-T12 and attenuated postexercise ischemic pressor response. Leg strength was reduced to 67 +/- 5% of control. At same relative force, increases in MABP and HR occurred more rapidly without than with epidural anesthesia (P less than 0.05). This difference was diminished during identical absolute force. Changes in plasma concentrations of catecholamines followed the pattern of HR and MABP responses, with differences between epidural and control experiments being most pronounced early in the work period. Plasma beta-endorphin was elevated only after control exercise. No response at 15% MVC was found for growth hormone, adrenocorticotropic hormone, insulin, glucagon, cortisol, glycerol, free fatty acids, or glucose (P greater than 0.05). In conclusion, during static exercise with large muscle groups and moderate relative force, modest changes in plasma hormones and metabolites take place. Furthermore, afferent nervous feedback from contracting muscles is important in regulation of blood pressure, heart rate, and catecholamine responses during static exercise in humans. |
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Authors:
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M Kjaer; N H Secher; F W Bach; H Galbo; D R Reeves; J H Mitchell |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The American journal of physiology Volume: 261 ISSN: 0002-9513 ISO Abbreviation: Am. J. Physiol. Publication Date: 1991 Aug |
Date Detail:
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Created Date: 1991-09-19 Completed Date: 1991-09-19 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0370511 Medline TA: Am J Physiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: E214-20 Citation Subset: IM |
Affiliation:
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Department of Anesthesia, Rigshospitalet, Denmark. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Anesthesia, Epidural* Blood Pressure* Exercise* Fatty Acids, Nonesterified / blood Glycerol / blood Heart Rate* Hormones / blood* Humans Lactates / blood Lactic Acid Male Metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Fatty Acids, Nonesterified; 0/Hormones; 0/Lactates; 50-21-5/Lactic Acid; 56-81-5/Glycerol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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