Document Detail

Hormonal, metabolic, and cardiovascular responses to static exercise in humans: influence of epidural anesthesia.
MedLine Citation:
PMID:  1872383     Owner:  NLM     Status:  MEDLINE    
To determine the role of reflex neural mechanisms for hormonal, metabolic, heart rate (HR), and blood pressure (MABP) changes during static exercise, seven health young males performed 10-min periods of two-legged static knee extension both during control and during epidural anesthesia. Comparisons were made at identical absolute (29 Nm) and relative [15% maximal voluntary contraction (MVC)] force. Afferent nerve blockade was verified by hypesthesia below T10-T12 and attenuated postexercise ischemic pressor response. Leg strength was reduced to 67 +/- 5% of control. At same relative force, increases in MABP and HR occurred more rapidly without than with epidural anesthesia (P less than 0.05). This difference was diminished during identical absolute force. Changes in plasma concentrations of catecholamines followed the pattern of HR and MABP responses, with differences between epidural and control experiments being most pronounced early in the work period. Plasma beta-endorphin was elevated only after control exercise. No response at 15% MVC was found for growth hormone, adrenocorticotropic hormone, insulin, glucagon, cortisol, glycerol, free fatty acids, or glucose (P greater than 0.05). In conclusion, during static exercise with large muscle groups and moderate relative force, modest changes in plasma hormones and metabolites take place. Furthermore, afferent nervous feedback from contracting muscles is important in regulation of blood pressure, heart rate, and catecholamine responses during static exercise in humans.
M Kjaer; N H Secher; F W Bach; H Galbo; D R Reeves; J H Mitchell
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The American journal of physiology     Volume:  261     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1991 Aug 
Date Detail:
Created Date:  1991-09-19     Completed Date:  1991-09-19     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  E214-20     Citation Subset:  IM    
Department of Anesthesia, Rigshospitalet, Denmark.
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MeSH Terms
Anesthesia, Epidural*
Blood Pressure*
Fatty Acids, Nonesterified / blood
Glycerol / blood
Heart Rate*
Hormones / blood*
Lactates / blood
Lactic Acid
Reg. No./Substance:
0/Fatty Acids, Nonesterified; 0/Hormones; 0/Lactates; 50-21-5/Lactic Acid; 56-81-5/Glycerol

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