Document Detail

Hormonal evidence supports the theory of selection in utero.
MedLine Citation:
PMID:  22411168     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: Antagonists in the debate over whether the maternal stress response during pregnancy damages or culls fetuses have invoked the theory of selection in utero to support opposing positions. We describe how these opposing arguments arise from the same theory and offer a novel test to discriminate between them. Our test, rooted in reports from population endocrinology that human chorionic gonadotropin (hCG) signals fetal fitness, contributes not only to the debate over the fetal origins of illness, but also to the more basic literature concerned with whether and how natural selection in utero affects contemporary human populations.
METHODS: We linked maternal serum hCG measurements from prenatal screening tests with data from the California Department of Public Health birth registry for the years 2001-2007. We used time series analysis to test the association between the number of live-born male singletons and median hCG concentration among males in monthly gestational cohorts.
RESULTS: Among the 1.56 million gestations in our analysis, we find that median hCG levels among male survivors of monthly conception cohorts rise as the number of male survivors falls.
RESULTS: Elevated median hCG among relatively small male birth cohorts supports the theory of selection in utero and suggests that the maternal stress response culls cohorts in gestation by raising the fitness criterion for survival to birth.
R A Catalano; K B Saxton; T A Bruckner; M Pearl; E Anderson; S Goldman-Mellor; C Margerison-Zilko; M Subbaraman; R J Currier; M Kharrazi
Related Documents :
7869448 - Traumatic separation of the symphysis pubis during pregnancy: a case report.
6418188 - Intravenous anaesthesia for minor surgery. a comparison of etomidate or althesin with f...
16132778 - Pregnancy in peritoneal dialysis: a case report and review of adequacy and outcomes.
11721118 - Safety and timing of nonobstetric abdominal surgery in pregnancy.
21926058 - Chlamydia trachomatis igg seropositivity is associated with lower natural conception ra...
14643178 - Alpha-linolenic acid supplementation during human pregnancy does not effect cognitive f...
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2012-03-12
Journal Detail:
Title:  American journal of human biology : the official journal of the Human Biology Council     Volume:  24     ISSN:  1520-6300     ISO Abbreviation:  Am. J. Hum. Biol.     Publication Date:    2012 Jul-Aug
Date Detail:
Created Date:  2012-06-11     Completed Date:  2012-10-11     Revised Date:  2013-07-03    
Medline Journal Info:
Nlm Unique ID:  8915029     Medline TA:  Am J Hum Biol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  526-32     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Wiley Periodicals, Inc.
School of Public Health, University of California Berkeley, Berkeley, California 94720-7360, USA. rayc@
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Abortion, Spontaneous / epidemiology,  etiology*
Birth Rate
California / epidemiology
Chorionic Gonadotropin / blood*
Cohort Studies
Fetal Death / epidemiology,  etiology*
Genetic Fitness
Infant Mortality / trends
Infant, Newborn
Live Birth
Models, Biological
Selection, Genetic*
Sex Ratio*
Stress, Physiological
Survival Analysis
Time Factors
Grant Support
R24 MH081797-01/MH/NIMH NIH HHS; R24 MH081797-01/MH/NIMH NIH HHS
Reg. No./Substance:
0/Chorionic Gonadotropin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Novel emissive bio-inspired non-proteinogenic coumarin-alanine amino acid: fluorescent probe for pol...
Next Document:  Airway epithelial cell differentiation during lung organogenesis requires C/EBP? and C/EBP?