Document Detail

Hormonal effects of apomorphine in schizophrenia.
MedLine Citation:
PMID:  6722395     Owner:  NLM     Status:  MEDLINE    
The hormonal effects of apomorphine, a direct-acting dopamine receptor agonist, in schizophrenic patients are of interest in view of the therapeutic efficacy of dopamine receptor antagonists. In this study, apomorphine (0.75 mg s.c.) and placebo were administered to unmedicated acute and chronic schizophrenics and controls. Apomorphine-induced prolactin suppression did not discriminate between the groups. However, an inverse relationship between basal prolactin levels and the severity of positive symptoms was detected in the patients with acute schizophrenia, consistent with a role for dopamine in the genesis of these symptoms. Growth hormone increments after apomorphine administration were blunted in the chronic schizophrenic patients, particularly those with 'negative' symptoms. It is argued that this blunting is not due to previous neuroleptic therapy and may represent evidence of structural change in the hypothalamus in this group of patients.
I N Ferrier; E C Johnstone; T J Crow
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The British journal of psychiatry : the journal of mental science     Volume:  144     ISSN:  0007-1250     ISO Abbreviation:  Br J Psychiatry     Publication Date:  1984 Apr 
Date Detail:
Created Date:  1984-07-11     Completed Date:  1984-07-11     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0342367     Medline TA:  Br J Psychiatry     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  349-57     Citation Subset:  IM    
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MeSH Terms
Acute Disease
Apomorphine / therapeutic use*
Chronic Disease
Estradiol / blood
Growth Hormone / blood
Luteinizing Hormone / blood
Middle Aged
Pituitary Hormones, Anterior / blood*
Prolactin / blood
Schizophrenia / blood*,  drug therapy
Reg. No./Substance:
0/Pituitary Hormones, Anterior; 50-28-2/Estradiol; 58-00-4/Apomorphine; 9002-62-4/Prolactin; 9002-67-9/Luteinizing Hormone; 9002-72-6/Growth Hormone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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