| Hormonal effects of apomorphine in schizophrenia. | |
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MedLine Citation:
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PMID: 6722395 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The hormonal effects of apomorphine, a direct-acting dopamine receptor agonist, in schizophrenic patients are of interest in view of the therapeutic efficacy of dopamine receptor antagonists. In this study, apomorphine (0.75 mg s.c.) and placebo were administered to unmedicated acute and chronic schizophrenics and controls. Apomorphine-induced prolactin suppression did not discriminate between the groups. However, an inverse relationship between basal prolactin levels and the severity of positive symptoms was detected in the patients with acute schizophrenia, consistent with a role for dopamine in the genesis of these symptoms. Growth hormone increments after apomorphine administration were blunted in the chronic schizophrenic patients, particularly those with 'negative' symptoms. It is argued that this blunting is not due to previous neuroleptic therapy and may represent evidence of structural change in the hypothalamus in this group of patients. |
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Authors:
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I N Ferrier; E C Johnstone; T J Crow |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The British journal of psychiatry : the journal of mental science Volume: 144 ISSN: 0007-1250 ISO Abbreviation: Br J Psychiatry Publication Date: 1984 Apr |
Date Detail:
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Created Date: 1984-07-11 Completed Date: 1984-07-11 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0342367 Medline TA: Br J Psychiatry Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 349-57 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acute Disease Adolescent Adult Aged Apomorphine / therapeutic use* Chronic Disease Estradiol / blood Growth Hormone / blood Humans Luteinizing Hormone / blood Male Middle Aged Pituitary Hormones, Anterior / blood* Prolactin / blood Schizophrenia / blood*, drug therapy |
| Chemical | |
Reg. No./Substance:
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0/Pituitary Hormones, Anterior; 50-28-2/Estradiol; 58-00-4/Apomorphine; 9002-62-4/Prolactin; 9002-67-9/Luteinizing Hormone; 9002-72-6/Growth Hormone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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