Document Detail


Hormonal effect on psoriasis in pregnancy and post partum.
MedLine Citation:
PMID:  15897382     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: To investigate prospectively how psoriasis fluctuates in pregnancy and post partum and to correlate hormone levels in pregnancy (progesterone and estrogens) with psoriatic change. DESIGN: Psoriatic body surface area (BSA) in pregnant patients with psoriasis (study group) and nonpregnant, menstruating patients with psoriasis (control group) were assessed 5 times over a year. Hormone levels (progesterone and estrogens) were measured in the study group and correlated with change in BSA. SETTING: University-affiliated obstetric and dermatology clinics. PATIENTS: Forty-seven pregnant patients in the psoriasis group and 27 nonpregnant, menstruating patients in the control group. RESULTS: During pregnancy, 55% of the patients reported improvement, 21% reported no change, and 23% reported worsening. However, post partum, only 9% of patients reported improvement, 26% reported no change, and 65% reported worsening. Psoriatic BSA decreased significantly from 10 to 20 weeks' gestation (P<.001) compared with controls, whereas BSA increased significantly by 6 weeks post partum (P = .001) compared with controls. In patients with 10% or greater psoriatic BSA who reported improvement (n = 16; mean BSA, 40%), lesions decreased by 83.8% during pregnancy. There were significant or near significant correlations between improvement in BSA and estradiol (P = .009, r = 0.648), estriol (P = .06, r = 0.491), and the ratio of estrogen to progesterone (P = .006, r = 0.671). CONCLUSION: High levels of estrogen correlated with improvement in psoriasis, whereas progesterone levels did not correlate with psoriatic change.
Authors:
Jenny E Murase; Kenneth K Chan; Thomas J Garite; Dan M Cooper; Gerald D Weinstein
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Archives of dermatology     Volume:  141     ISSN:  0003-987X     ISO Abbreviation:  Arch Dermatol     Publication Date:  2005 May 
Date Detail:
Created Date:  2005-05-17     Completed Date:  2005-06-20     Revised Date:  2008-03-17    
Medline Journal Info:
Nlm Unique ID:  0372433     Medline TA:  Arch Dermatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  601-6     Citation Subset:  AIM; IM    
Affiliation:
Department of Dermatology, University of California, Irvine 92697, USA. jemurase@uci.edu
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MeSH Terms
Descriptor/Qualifier:
Adult
Body Surface Area
Case-Control Studies
Estradiol / blood
Estriol / blood
Estrogens / blood*
Female
Humans
Menstruation / blood
Postpartum Period
Pregnancy
Pregnancy Complications / blood,  pathology,  physiopathology*
Progesterone / blood*
Psoriasis / blood,  pathology,  physiopathology*
Grant Support
ID/Acronym/Agency:
5T35GM08630/GM/NIGMS NIH HHS; M01 RR00827/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
0/Estrogens; 50-27-1/Estriol; 50-28-2/Estradiol; 57-83-0/Progesterone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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