Document Detail

Hormonal changes during a 20-week confinement.
MedLine Citation:
PMID:  9819159     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: When the European Space Agency planned the EUROMIR'95 long-duration flight with a European astronaut on board the Russian orbital MIR station, it organized simultaneously a ground simulation, called the Human Behaviour Study, of this manned space mission. The ground simulation was a confinement experiment, and this paper describes the changes in volume-regulating hormones that occurred during and after 20 weeks of confinement. METHODS: In a normobaric diving chamber, 3 subjects were confined for 135 d. Arterial pressure, plasma concentrations of blood volume-regulating hormones (active renin and arginine-vasopressin), and urinary variables (aldosterone, arginine-vasopressin, and metabolites of catecholamines) were measured before, during, and after confinement. RESULTS: Arterial pressure was increased from week 1 until week 15 of confinement, while heart rate was elevated from week 6 until the end of the simulation. Plasma active renin was elevated throughout the confinement (after week 6). Urine volume increased transitively on the first 2 d of confinement. CONCLUSIONS: The results obtained during this long-term confinement experiment have major importance regarding concerns about spaceflight and bed rest data, because we observed hormonal changes during the experiment that normally are assigned to the fluid shift that occurs in weightlessness or in the head-down tilt position (i.e., an increase of renin, an increase of urinary volume during the first two days, and a decreased urinary cyclic guanosine monophosphate.
A Maillet; J Titze; V Gushin; I Nichiporuk; K A Kirsch; C Gharib; G Gauquelin-Koch
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Aviation, space, and environmental medicine     Volume:  69     ISSN:  0095-6562     ISO Abbreviation:  Aviat Space Environ Med     Publication Date:  1998 Nov 
Date Detail:
Created Date:  1999-01-20     Completed Date:  1999-01-20     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7501714     Medline TA:  Aviat Space Environ Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1045-51     Citation Subset:  IM; S    
Laboratoire de Physiologie de l'Environnement, Faculté de Médecine Lyon Grange-Blanche, France.
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MeSH Terms
Aldosterone / metabolism*
Arginine / metabolism*
Blood Pressure
Body Mass Index
Catecholamines / metabolism*
Ecological Systems, Closed*
Energy Intake
Fluid Shifts / physiology*
Heart Rate
Renin / metabolism*
Space Simulation / adverse effects*
Time Factors
Vasopressins / metabolism*
Reg. No./Substance:
0/Catecholamines; 11000-17-2/Vasopressins; 52-39-1/Aldosterone; 74-79-3/Arginine; EC

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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