| Hormonal and body-size factors in relation to breast cancer risk: a prospective study of 11,889 women in a low-incidence area. | |
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MedLine Citation:
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PMID: 15996484 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: This prospective cohort study of 11,889 women was conducted to determine significant factors associated with the risk of breast cancer among Chinese women in Taiwan, a low-incidence area. METHODS: In-person interviews were completed for subjects to solicit information on hormonal factors. Measurements of height, weight, and waist-and- hip circumferences were performed by well-trained assistants using standardized techniques. Cox proportional hazards models were employed to estimate relative risks (RRs) and 95% confidence intervals (CIs). RESULTS: During an average follow-up time of 10.3 years (range: 1 to 11 years) with an accumulation of 134,063 person-years, 104 incident breast cancer cases were identified through data linkage with national cancer registry profile. There was a significant elevation in breast-cancer risk with increasing duration of the interval between age at menarche and age at first full-term pregnancy (FFTP). Additionally, central adiposity reflected by hip circumference was a significant predictor of breast cancer in this Chinese female population. CONCLUSIONS: The findings of this study indicated common mechanisms responsible for the higher incidence of breast cancer in Western populations may also explain the risk of breast cancer development in Taiwan, a low-incidence area. |
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Authors:
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Mei-Hsuan Wu; Yu-Ching Chou; Jyh-Cherng Yu; Cheng-Pung Yu; Cho-Chieh Wu; Chi-Ming Chu; Tsan Yang; Ching-Huang Lai; Chang-Yao Hsieh; San-Lin You; Chien-Jen Chen; Chien-An Sun |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2005-06-29 |
Journal Detail:
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Title: Annals of epidemiology Volume: 16 ISSN: 1047-2797 ISO Abbreviation: Ann Epidemiol Publication Date: 2006 Mar |
Date Detail:
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Created Date: 2006-02-21 Completed Date: 2006-06-29 Revised Date: 2008-06-23 |
Medline Journal Info:
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Nlm Unique ID: 9100013 Medline TA: Ann Epidemiol Country: United States |
Other Details:
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Languages: eng Pagination: 223-9 Citation Subset: IM |
Affiliation:
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School of Public Health, National Defense Medical Center, Taipei 114, Taiwan, Republic of China. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Age Factors Aged Aged, 80 and over Body Mass Index Body Size* Breast Neoplasms / epidemiology*, metabolism China / ethnology Cohort Studies Female Hormones / metabolism* Humans Menarche Middle Aged Pregnancy Proportional Hazards Models Prospective Studies Risk Factors Taiwan / epidemiology |
| Chemical | |
Reg. No./Substance:
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0/Hormones |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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