| Hormonal Therapy for Epilepsy. | |
| | |
MedLine Citation:
|
PMID: 21451944 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
In 2011, there are greater than 20 antiepileptic medications available. These medications work by modulating neuronal excitability. Reproductive hormones have been found to have a role in the pathogenesis and treatment of seizures by also altering neuronal excitability, especially in women with catamenial epilepsy. The female reproductive hormones have in general opposing effects on neuronal excitability; estrogens generally impart a proconvulsant neurophysiologic tone, whereas the progestogens have anticonvulsant effects. It follows then that fluctuations in the levels of serum progesterone and estrogen throughout a normal reproductive cycle bring about an increased or decreased risk of seizure occurrence based upon the serum estradiol/progesterone ratio. Therefore, using progesterone, its metabolite allopregnanolone, or other hormonal therapies have been explored in the treatment of patients with epilepsy. |
| | |
Authors:
|
Scott J Stevens; Cynthia L Harden |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-3-31 |
Journal Detail:
|
Title: Current neurology and neuroscience reports Volume: - ISSN: 1534-6293 ISO Abbreviation: - Publication Date: 2011 Mar |
Date Detail:
|
Created Date: 2011-3-31 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 100931790 Medline TA: Curr Neurol Neurosci Rep Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
Neurology, Hofstra North Shore-LIJ School of Medicine, Division of Epilepsy and Electroencephalography, Harvey Cushing Institutes of Neuroscience, North Shore-Long Island Jewish Health System, 270-05 76th Avenue, New Hyde Park, NY, 11040, USA, sstevens2@nshs.edu. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Sympathetic Mechanisms, Organ Damage, and Antihypertensive Treatment.
Next Document: ShopTalk: a pilot study of the feasibility and utility of a therapeutic board game for youth living ...