Document Detail


Hormonal Therapy for Epilepsy.
MedLine Citation:
PMID:  21451944     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
In 2011, there are greater than 20 antiepileptic medications available. These medications work by modulating neuronal excitability. Reproductive hormones have been found to have a role in the pathogenesis and treatment of seizures by also altering neuronal excitability, especially in women with catamenial epilepsy. The female reproductive hormones have in general opposing effects on neuronal excitability; estrogens generally impart a proconvulsant neurophysiologic tone, whereas the progestogens have anticonvulsant effects. It follows then that fluctuations in the levels of serum progesterone and estrogen throughout a normal reproductive cycle bring about an increased or decreased risk of seizure occurrence based upon the serum estradiol/progesterone ratio. Therefore, using progesterone, its metabolite allopregnanolone, or other hormonal therapies have been explored in the treatment of patients with epilepsy.
Authors:
Scott J Stevens; Cynthia L Harden
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-3-31
Journal Detail:
Title:  Current neurology and neuroscience reports     Volume:  -     ISSN:  1534-6293     ISO Abbreviation:  -     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-3-31     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100931790     Medline TA:  Curr Neurol Neurosci Rep     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Neurology, Hofstra North Shore-LIJ School of Medicine, Division of Epilepsy and Electroencephalography, Harvey Cushing Institutes of Neuroscience, North Shore-Long Island Jewish Health System, 270-05 76th Avenue, New Hyde Park, NY, 11040, USA, sstevens2@nshs.edu.
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