| Hormonal modulation of two coordinated rhythmic motor patterns. | |
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MedLine Citation:
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PMID: 20522781 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Neuromodulation is well known to provide plasticity in pattern generating circuits, but few details are available concerning modulation of motor pattern coordination. We are using the crustacean stomatogastric nervous system to examine how co-expressed rhythms are modulated to regulate frequency and maintain coordination. The system produces two related motor patterns, the gastric mill rhythm that regulates protraction and retraction of the teeth and the pyloric rhythm that filters food. These rhythms have different frequencies and are controlled by distinct mechanisms, but each circuit influences the rhythm frequency of the other via identified synaptic pathways. A projection neuron, MCN1, activates distinct versions of the rhythms, and we show that hormonal dopamine concentrations modulate the MCN1 elicited rhythm frequencies. Gastric mill circuit interactions with the pyloric circuit lead to changes in pyloric rhythm frequency that depend on gastric mill rhythm phase. Dopamine increases pyloric frequency during the gastric mill rhythm retraction phase. Higher gastric mill rhythm frequencies are associated with higher pyloric rhythm frequencies during retraction. However, dopamine slows the gastric mill rhythm frequency despite the increase in pyloric frequency. Dopamine reduces pyloric circuit influences on the gastric mill rhythm and upregulates activity in a gastric mill neuron, DG. Strengthened DG activity slows the gastric mill rhythm frequency and effectively reduces pyloric circuit influences, thus changing the frequency relationship between the rhythms. Overall dopamine shifts dependence of frequency regulation from intercircuit interactions to increased reliance on intracircuit mechanisms. |
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Authors:
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Debra E Wood; Melissa Varrecchia; Michael Papernov; Denise Cook; Devon C Crawford |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S. Date: 2010-06-02 |
Journal Detail:
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Title: Journal of neurophysiology Volume: 104 ISSN: 1522-1598 ISO Abbreviation: J. Neurophysiol. Publication Date: 2010 Aug |
Date Detail:
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Created Date: 2010-08-16 Completed Date: 2010-12-01 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0375404 Medline TA: J Neurophysiol Country: United States |
Other Details:
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Languages: eng Pagination: 654-64 Citation Subset: IM |
Affiliation:
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Department of Biology, Case Western Reserve University, Degrace Hall 106, Cleveland, Ohio 44106, USA. dew6@case.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Action Potentials
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drug effects Analysis of Variance Animals Brachyura Dopamine / pharmacology* Dopamine Agents / pharmacology* Ganglia, Invertebrate / cytology Male Motor Activity / drug effects, physiology* Neural Pathways / drug effects Neurons / drug effects*, physiology Periodicity* |
| Chemical | |
Reg. No./Substance:
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0/Dopamine Agents |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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