Document Detail

Hormetic effects of reactive oxygen species by exercise: a view from animal studies for successful aging in human.
MedLine Citation:
PMID:  20221292     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Numerous anti-aging measures have been proposed to cope with age-associated decline of physiological functions and/or onset of diseases, mostly based on free radical (or oxidative stress) theory of aging, though no robust scientific data have been reported to extend human healthspan. This is due to dual (harmful as well as essential) roles of reactive oxygen species (ROS) to a body. Regular moderate exercise provides benefits upregulating defense against oxidative stress in good balance between the opposing dual roles. Sources of ROS in exercise appear to be not only mitochondria as often claimed but also enzymatic reactions catalyzed by NADPH oxidase and other oxidases. It may, therefore, be possible to mimic this aspect of exercise to promote the defense for healthspan extension by other means such as modest alcohol consumption that could upregulate activity of enzymes against oxidative stress.
Sataro Goto; Zsolt Radák
Publication Detail:
Type:  Journal Article     Date:  2009-12-14
Journal Detail:
Title:  Dose-response : a publication of International Hormesis Society     Volume:  8     ISSN:  1559-3258     ISO Abbreviation:  Dose Response     Publication Date:  2009  
Date Detail:
Created Date:  2010-03-11     Completed Date:  2011-07-14     Revised Date:  2013-05-29    
Medline Journal Info:
Nlm Unique ID:  101308899     Medline TA:  Dose Response     Country:  United States    
Other Details:
Languages:  eng     Pagination:  68-72     Citation Subset:  -    
Juntendo University Graduate School, Institute of Health and Sports Science & Medicine, Hiragagakuendai 1-1, Inbagun, Chiba, Japan.
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