Document Detail


Horizontal transmission of Candida parapsilosis candidemia in a neonatal intensive care unit.
MedLine Citation:
PMID:  12089249     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This report describes the nosocomial acquisition of Candida parapsilosis candidemia by one of the six premature newborns housed in the same room of a neonatal intensive care unit at the Ospedale Santa Chiara, Pisa, Italy. The infant had progeria, a disorder characterized by retarded physical development and progressive senile degeneration. The infant, who was not found to harbor C. parapsilosis at the time of his admission to the intensive care unit, had exhibited symptomatic conjunctivitis before the onset of a severe bloodstream infection. In order to evaluate the source of infection and the route of transmission, two independent molecular typing methods were used to determine the genetic relatedness among the isolates recovered from the newborn, the inanimate hospital environment, hospital personnel, topically and intravenously administered medicaments, and indwelling catheters. Among the isolates collected, only those recovered from the hands of two nurses attending the newborns and from both the conjunctiva and the blood of the infected infant were genetically indistinguishable. Since C. parapsilosis was never recovered from indwelling catheters or from any of the drugs administered to the newborn, we concluded that (i) horizontal transmission of C. parapsilosis occurred through direct interaction between nurses and the newborn and (ii) the conjunctiva was the site through which C. parapsilosis entered the bloodstream. This finding highlights the possibility that a previous C. parapsilosis colonization and/or infection of other body sites may be a predisposing condition for subsequent C. parapsilosis hematogenous dissemination in severely ill newborns.
Authors:
Antonella Lupetti; Arianna Tavanti; Paola Davini; Emilia Ghelardi; Valerio Corsini; Ilaria Merusi; Antonio Boldrini; Mario Campa; Sonia Senesi
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of clinical microbiology     Volume:  40     ISSN:  0095-1137     ISO Abbreviation:  J. Clin. Microbiol.     Publication Date:  2002 Jul 
Date Detail:
Created Date:  2002-06-28     Completed Date:  2002-08-26     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  7505564     Medline TA:  J Clin Microbiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2363-9     Citation Subset:  IM    
Affiliation:
Dipartimento di Patologia Sperimentale, Biotecnologie Mediche, Infettivologia ed Epidemiologia, Università degli Studi di Pisa, Pisa, Italy.
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MeSH Terms
Descriptor/Qualifier:
Candida / genetics,  isolation & purification
Candidiasis / complications,  microbiology,  transmission*
Conjunctiva / microbiology
Cross Infection / complications,  microbiology,  transmission*
DNA Fingerprinting
DNA, Fungal / genetics,  isolation & purification
Environmental Microbiology
Fungemia / complications,  microbiology,  transmission*
Humans
Infant, Newborn
Infant, Premature
Infectious Disease Transmission, Professional-to-Patient
Intensive Care Units, Neonatal
Italy
Karyotyping
Male
Nursing Staff, Hospital
Progeria / complications
Random Amplified Polymorphic DNA Technique
Skin / microbiology
Chemical
Reg. No./Substance:
0/DNA, Fungal
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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