Document Detail

Hop (Humulus lupulus)-derived bitter acids as multipotent bioactive compounds.
MedLine Citation:
PMID:  19476340     Owner:  NLM     Status:  MEDLINE    
Hop acids, a family of bitter compounds derived from the hop plant (Humulus lupulus), have been reported to exert a wide range of effects, both in vitro and in vivo. They exhibit potential anticancer activity by inhibiting cell proliferation and angiogenesis, by inducing apoptosis, and by increasing the expression of cytochrome P450 detoxification enzymes. Furthermore, hop bitter acids are effective against inflammatory and metabolic disorders, which makes them challenging candidates for the treatment of diabetes mellitus, cardiovascular diseases, and metabolic syndrome. This review summarizes the current knowledge on hop bitter acids, including both phytochemical aspects, as well as the biological and pharmacological properties of these compounds.
Marjan Van Cleemput; Ko Cattoor; Karolien De Bosscher; Guy Haegeman; Denis De Keukeleire; Arne Heyerick
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Journal of natural products     Volume:  72     ISSN:  1520-6025     ISO Abbreviation:  J. Nat. Prod.     Publication Date:  2009 Jun 
Date Detail:
Created Date:  2009-06-26     Completed Date:  2009-07-23     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7906882     Medline TA:  J Nat Prod     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1220-30     Citation Subset:  IM    
Laboratory of Pharmacognosy and Phytochemistry, Ghent University-UGent, Gent, Belgium.
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MeSH Terms
Acids / analysis,  pharmacology*
Antineoplastic Agents, Phytogenic / isolation & purification,  pharmacology*
Apoptosis / drug effects
Central Nervous System / drug effects*
Disease Models, Animal
Humulus / chemistry*
Plants, Medicinal / chemistry*
Reg. No./Substance:
0/Acids; 0/Antineoplastic Agents, Phytogenic

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