| Hop (Humulus lupulus)-derived bitter acids as multipotent bioactive compounds. | |
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MedLine Citation:
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PMID: 19476340 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Hop acids, a family of bitter compounds derived from the hop plant (Humulus lupulus), have been reported to exert a wide range of effects, both in vitro and in vivo. They exhibit potential anticancer activity by inhibiting cell proliferation and angiogenesis, by inducing apoptosis, and by increasing the expression of cytochrome P450 detoxification enzymes. Furthermore, hop bitter acids are effective against inflammatory and metabolic disorders, which makes them challenging candidates for the treatment of diabetes mellitus, cardiovascular diseases, and metabolic syndrome. This review summarizes the current knowledge on hop bitter acids, including both phytochemical aspects, as well as the biological and pharmacological properties of these compounds. |
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Authors:
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Marjan Van Cleemput; Ko Cattoor; Karolien De Bosscher; Guy Haegeman; Denis De Keukeleire; Arne Heyerick |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Journal of natural products Volume: 72 ISSN: 1520-6025 ISO Abbreviation: J. Nat. Prod. Publication Date: 2009 Jun |
Date Detail:
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Created Date: 2009-06-26 Completed Date: 2009-07-23 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7906882 Medline TA: J Nat Prod Country: United States |
Other Details:
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Languages: eng Pagination: 1220-30 Citation Subset: IM |
Affiliation:
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Laboratory of Pharmacognosy and Phytochemistry, Ghent University-UGent, Gent, Belgium. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acids
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analysis,
pharmacology* Animals Antineoplastic Agents, Phytogenic / isolation & purification, pharmacology* Apoptosis / drug effects Central Nervous System / drug effects* Disease Models, Animal Humans Humulus / chemistry* Mice Plants, Medicinal / chemistry* Rats |
| Chemical | |
Reg. No./Substance:
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0/Acids; 0/Antineoplastic Agents, Phytogenic |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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