| Honokiol: a novel natural agent for cancer prevention and therapy. | |
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MedLine Citation:
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PMID: 22834827 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Honokiol ((3,5-di-(2-propenyl)-1,1-biphenyl-2,2-diol) is a bioactive natural product derived from Magnolia spp. Recent studies have demonstrated anti-inflammatory, anti-angiogenic, anti-oxidative and anti-cancer properties of honokiol in vitro and in preclinical models. Honokiol targets multiple signaling pathways including nuclear factor kappa B (NF-κB), signal transducers and activator of transcription 3 (STAT3), epidermal growth factor receptor (EGFR) and mammalian target of rapamycin (m-TOR), which have great relevance during cancer initiation and progression. Furthermore, pharmacokinetic profile of honokiol has revealed a desirable spectrum of bioavailability after intravenous administration in animal models, thus making it a suitable agent for clinical trials. In this review, we discuss recent data describing the molecular targets of honokiol and its anti-cancer activities against various malignancies in pre-clinical models. Evaluation of honokiol in clinical trials will be the next step towards its possible human applications. |
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Authors:
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Sumit Arora; Seema Singh; Gary A Piazza; Carlo M Contreas; Jayanth Panyam; Ajay P Singh |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-7-23 |
Journal Detail:
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Title: Current molecular medicine Volume: - ISSN: 1875-5666 ISO Abbreviation: - Publication Date: 2012 Jul |
Date Detail:
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Created Date: 2012-7-27 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101093076 Medline TA: Curr Mol Med Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Department of Oncologic Sciences, Mitchell Cancer Institute, University of South Alabama, 1660 Springhill Avenue Mobile, AL 36604-1405, USA. asingh@usouthal.edu. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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