| Honokiol induces apoptosis via cytochrome c release and caspase activation in activated rat hepatic stellate cells in vitro. | |
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MedLine Citation:
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PMID: 15678380 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The therapeutic goal in liver fibrosis is the reversal of fibrosis and the selective clearance of activated hepatic stellate cells (HSCs) by inducing apoptosis. Over the past several years, we have screened for natural products that mediate apoptosis in activated HSCs. Among the candidate compounds, honokiol, isolated from Magnoliae cortex, was found to induce apoptotic death in activated rat HSCs, while there was no cell viability change in hepatocytes, at concentrations of 12.5-50 microM. Apoptosis was identified by DNA fragmentation, activation of caspase-3 and -9, and the proteolytic cleavage of poly(ADP-ribose) polymerase, down-regulation of bcl-2 and the release of mitochondrial cytochrome c into the cytoplasm. |
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Authors:
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Eun-Jeon Park; Yu-Zhe Zhao; Young Ho Kim; Byung-Hoon Lee; Dong Hwan Sohn |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Planta medica Volume: 71 ISSN: 0032-0943 ISO Abbreviation: Planta Med. Publication Date: 2005 Jan |
Date Detail:
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Created Date: 2005-01-28 Completed Date: 2005-03-29 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0066751 Medline TA: Planta Med Country: Germany |
Other Details:
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Languages: eng Pagination: 82-4 Citation Subset: IM |
Affiliation:
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Department of Pharmacy, Medicinal Resources Research Center, Wonkwang University, Iksan, Jeonbuk, Korea. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antineoplastic Agents, Phytogenic / administration & dosage, pharmacology*, therapeutic use Apoptosis / drug effects* Biphenyl Compounds / administration & dosage, pharmacology*, therapeutic use Caspases / metabolism Cytochromes c / metabolism Dose-Response Relationship, Drug Drugs, Chinese Herbal / administration & dosage, pharmacology*, therapeutic use Enzyme Activation / drug effects Flow Cytometry Hepatocytes / drug effects, enzymology, metabolism Lignans / administration & dosage, pharmacology*, therapeutic use Magnolia* Male Phytotherapy* Rats Rats, Sprague-Dawley |
| Chemical | |
Reg. No./Substance:
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0/Antineoplastic Agents, Phytogenic; 0/Biphenyl Compounds; 0/Drugs, Chinese Herbal; 0/Lignans; 35354-74-6/honokiol; 9007-43-6/Cytochromes c; EC 3.4.22.-/Caspases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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