| Honokiol Attenuates the Severity of Acute Pancreatitis and Associated Lung Injury via Acceleration of Acinar Cell Apoptosis. | |
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MedLine Citation:
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PMID: 22258232 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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ABSTRACT: Severe acute pancreatitis remains a life threatening disease with a high mortality rate among a defined proportion of those affected. Apoptosis has been hypothesized to be a beneficial form of cell death in acute pancreatitis. Honokiol, a small molecular weight natural product, possesses the ability of anti-inflammation and apoptosis induction. Here, we investigate whether honokiol can ameliorate severe acute pancreatitis and associated acute lung injury in a mouse model. Mice were received six injections of cerulein at 1-hour intervals, then given a mouse model. Mice were received six injections of cerulein at 1-hour intervals, then given pancreatitis. Moreover, mice were intraperitoneally given vehicle or honokiol 10 min after the first cerulein injection. Honokiol protected against the severity of acute pancreatitis in terms of increased serum amylase and lipase levels, pancreas pathological injury and associated acute lung injury. Honokiol significantly reduced the increases in serum TNF-α, IL-6, and nitric oxide levels 3 hours and serum high mobility group box 1 (HMGB1) 24 hours after acute pancreatitis induction. Honokiol also significantly decreased myeloperoxidase activities in pancreas and lungs. Endoplasmic reticulum stress-related molecules eIF2α (phosphorylated) and CHOP protein expressions, apoptosis, and caspase-3 activity were increased in the pancreas of mice with severe acute pancreatitis, which was unexpectedly enhanced by honokiol treatment. These results suggest that honokiol protects against the acute pancreatitis and limits the spread of inflammatory damage to the lung in asevere acute pancreatitis mouse model. The acceleration of pancreatic cell apoptosis by honokiol may play a pivotal role. |
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Authors:
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Te I Weng; Hsiao Yi Wu; Bo Lin Chen; Shing Hwa Liu |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-1-17 |
Journal Detail:
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Title: Shock (Augusta, Ga.) Volume: - ISSN: 1540-0514 ISO Abbreviation: - Publication Date: 2012 Jan |
Date Detail:
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Created Date: 2012-1-19 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9421564 Medline TA: Shock Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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* Department of Forensic Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan; † Departments of Emergency Medicine, National Taiwan University Hospital, Taipei, Taiwan; ‡ Institute of Toxicology, College of Medicine, National Taiwan University, Taipei, Taiwan; ¶ Department of Urology, National Taiwan University Hospital, Taipei, Taiwan. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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