Document Detail

Honeybee royal jelly inhibits autoimmunity in SLE-prone NZB x NZW F1 mice.
MedLine Citation:
PMID:  19074168     Owner:  NLM     Status:  MEDLINE    
Royal jelly (RJ) is a gelatinous secretion from young nurse worker bees (Apis mellifera), which serves as the sole food for the queen bee. Because of its pleiotropic functions for queen bees, RJ has also been used as a dietary supplement with various health benefits for humans. Because RJ is being indicated to have immunomodulatory potential for humans, we undertook the study to determine whether the oral administration of RJ could alter the development of systemic autoimmunity in New Zealand Black (NZB) x New Zealand White (NZW) F1 mice that genetically exhibit many manifestations similar to human systemic lupus erythematosus (SLE). We herein reported that mice administered with RJ showed a significant delay in the onset of the disease, as manifested by decreased proteinuria and a prolongation of lifespan. In addition, RJ administration after the onset of the disease significantly improved the renal symptoms, leading to an extended lifespan. RJ administration to mice caused a significant decrease in the serum level of IL-10, and in the autoantibodies against ssDNA, dsDNA and erythrocytes, as well as a reduction in the number of splenic autoreactive B cells. In conclusion, our data suggest that the use of RJ may be beneficial in the prevention of the early onset of SLE and in the control of the active progression of the manifestations of SLE.
M K Mannoor; I Shimabukuro; M Tsukamotoa; H Watanabe; K Yamaguchi; Y Sato
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Lupus     Volume:  18     ISSN:  0961-2033     ISO Abbreviation:  Lupus     Publication Date:  2009 Jan 
Date Detail:
Created Date:  2008-12-16     Completed Date:  2009-03-24     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9204265     Medline TA:  Lupus     Country:  England    
Other Details:
Languages:  eng     Pagination:  44-52     Citation Subset:  IM    
Department of Social and Environmental Medicine, Faculty of Medicine, University of the Ryukyus, Okinawa, Japan.
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MeSH Terms
Administration, Oral
Autoantibodies / drug effects*,  metabolism
Autoimmunity / drug effects*
DNA / drug effects,  metabolism
Disease Models, Animal
Erythrocytes / drug effects,  metabolism
Fatty Acids / pharmacology*,  therapeutic use
Interleukin-10 / blood
Longevity / drug effects
Lupus Erythematosus, Systemic / drug therapy*,  physiopathology
Mice, Inbred NZB
Proteinuria / drug therapy,  etiology
Reg. No./Substance:
0/Autoantibodies; 0/Fatty Acids; 130068-27-8/Interleukin-10; 8031-67-2/royal jelly; 9007-49-2/DNA

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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