Document Detail


Honey-induced stimulation of blood ethanol elimination and its influence on serum triacylglycerol and blood pressure in man.
MedLine Citation:
PMID:  16088097     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effect of honey on blood alcohol metabolism and the accompanying changes in serum triacylglycerol and blood pressure were investigated using volunteers. Fifty consenting undergraduates in apparent good health, between the ages of 15 and 30 years (23.6 +/- 7.4), were recruited for the study. The subjects were moderate alcohol drinkers (<30 g ethanol/day), matched in body weight and frame size. The participants were given ethanol (0.5 g/kg) and ethanol + honey (0.5 g/kg + 1.25 ml/kg) on two different occasions separated by 1 week. The results show that honey significantly (p < 0.01) increased blood alcohol disappearance and elimination rates by 32.4 and 28.6%, respectively, but reduced the intoxication time (that is, the time taken to attain zero blood alcohol level) and its degree (the peak blood alcohol level) by 30.0 and 4.4%. Ethanol + honey further increased serum triacylglycerol and blood pressure by 20.8 and 1.3/1.4% when compared with the proportion induced by ethanol after about 10 h of ingestion. The occasional use of honey as an anti-intoxicating agent may be approved. Meanwhile, further studies on how to ameliorate or prevent the associated increase in serum triacylglycerol and blood pressure is required.
Authors:
I Onyesom
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial     Date:  2005-08-04
Journal Detail:
Title:  Annals of nutrition & metabolism     Volume:  49     ISSN:  0250-6807     ISO Abbreviation:  Ann. Nutr. Metab.     Publication Date:    2005 Sep-Oct
Date Detail:
Created Date:  2005-09-13     Completed Date:  2005-12-12     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8105511     Medline TA:  Ann Nutr Metab     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  319-24     Citation Subset:  IM    
Copyright Information:
Copyright (c) 2005 S. Karger AG, Basel.
Affiliation:
Department of Medical Biochemistry, Delta State University, Abraka, Nigeria. onyesominno@yahoo.co.uk
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MeSH Terms
Descriptor/Qualifier:
Administration, Oral
Adolescent
Adult
Alcoholic Intoxication / prevention & control*
Blood Pressure / drug effects*
Citrus
Cross-Over Studies
Ethanol / blood,  metabolism,  pharmacokinetics*
Female
Honey*
Humans
Liver / drug effects,  metabolism
Male
Nigeria
Sex Factors
Triglycerides / blood*
Chemical
Reg. No./Substance:
0/Triglycerides; 64-17-5/Ethanol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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