Document Detail

Homozygous factor V Leiden mutation in a woman with multiple adverse pregnancy outcomes.
MedLine Citation:
PMID:  11129520     Owner:  NLM     Status:  MEDLINE    
We report a case with one intrauterine fetal death (IUFD) at 32 weeks of gestation, one premature delivery at the same week, and one abortion of unknown etiology at 12 weeks of gestation. We discuss that the presence of homozygosity for Factor V Leiden may be associated with placental insufficiency in this woman. Application of anticoagulant therapy may have been beneficial in her current pregnancy.
H U Pauer; J Neesen; M Schloesser; B Hinney; R Rauskolb
Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Archives of gynecology and obstetrics     Volume:  264     ISSN:  0932-0067     ISO Abbreviation:  Arch. Gynecol. Obstet.     Publication Date:  2000 Nov 
Date Detail:
Created Date:  2000-12-20     Completed Date:  2001-02-08     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8710213     Medline TA:  Arch Gynecol Obstet     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  164-5     Citation Subset:  IM    
Department of Gynecology and Obstetrics, University of Goettingen, Germany.
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MeSH Terms
Abortion, Habitual / genetics*
Anticoagulants / therapeutic use
Coagulation Protein Disorders / diagnosis*,  drug therapy,  genetics
Factor V / genetics*
Point Mutation
Pregnancy Complications, Hematologic / diagnosis*,  drug therapy
Reg. No./Substance:
0/Anticoagulants; 0/factor V Leiden; 9001-24-5/Factor V

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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