Document Detail


Homozygous deletion mapping at 9p21 in bladder carcinoma defines a critical region within 2cM of IFNA.
MedLine Citation:
PMID:  8058343     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We have screened 165 cases of primary transitional cell carcinoma of the bladder for loss of heterozygosity of markers on chromosome 9. High density deletion mapping was then carried out on a panel of 16 tumours with partial deletions of 9p using 15 microsatellite markers. Seven tumours had hemizygous deletions which included small interstitial losses and large terminal deletions. Homozygous deletions of one or more markers were identified in the remaining 9 tumours. By comparing the limits of hemi- and homozygous deletions in these tumours we have defined a single common region of 2cM flanked by IFNA and D9S171.
Authors:
J Devlin; A J Keen; M A Knowles
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Oncogene     Volume:  9     ISSN:  0950-9232     ISO Abbreviation:  Oncogene     Publication Date:  1994 Sep 
Date Detail:
Created Date:  1994-09-15     Completed Date:  1994-09-15     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8711562     Medline TA:  Oncogene     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  2757-60     Citation Subset:  IM    
Affiliation:
Molecular Genetics Laboratory, Marie Curie Research Institute, Oxted, Surrey.
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MeSH Terms
Descriptor/Qualifier:
Chromosome Deletion*
Chromosome Mapping
Chromosomes, Human, Pair 9*
Homozygote
Humans
Polymerase Chain Reaction
Urinary Bladder Neoplasms / genetics*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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