Document Detail


Homozygosity mapping of the locus responsible for renal tubular dysplasia of cattle on bovine chromosome 1.
MedLine Citation:
PMID:  10754108     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Renal tubular dysplasia is a hereditary disease of Japanese black cattle showing renal failure and growth retardation with an autosomal recessive trait. In the present study, we mapped the locus responsible for the disease (RTD) by linkage analysis with an inbred paternal half-sib pedigree obtained from commercial herds. By analyzing segregation of microsatellite markers in the half-sibs, significant linkage was observed between the RTD locus and markers on bovine Chromosome (Chr) 1 with the highest lod score of 11.4. Homozygosity mapping with the inbred pedigree further defined the localization of the RTD locus in a 4-cM region between microsatellite markers BMS4003 and INRA119. Mapping of the RTD locus on bovine Chr 1 will facilitate cloning and characterization of the gene responsible for this disease.
Authors:
Y Ohba; H Kitagawa; K Kitoh; S Asahina; K Nishimori; K Yoneda; T Kunieda; Y Sasaki
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Mammalian genome : official journal of the International Mammalian Genome Society     Volume:  11     ISSN:  0938-8990     ISO Abbreviation:  Mamm. Genome     Publication Date:  2000 Apr 
Date Detail:
Created Date:  2000-05-19     Completed Date:  2000-05-19     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9100916     Medline TA:  Mamm Genome     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  316-9     Citation Subset:  IM    
Affiliation:
Division of Veterinary Medicine, Faculty of Agriculture, Gifu University, Yanagido, Japan.
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MeSH Terms
Descriptor/Qualifier:
Animals
Cattle
Chromosome Mapping / veterinary*
Female
Genetic Markers
Homozygote*
Kidney Tubules / abnormalities*
Linkage (Genetics)
Male
Microsatellite Repeats / genetics
Pedigree
Chemical
Reg. No./Substance:
0/Genetic Markers

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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